Specification of anteroposterior cell fates in Caenorhabditis elegans by Drosophila Hox proteins
Specification of anteroposterior cell fates in Caenorhabditis elegans by Drosophila Hox proteins
复制标题
果蝇 Hox 蛋白对秀丽隐杆线虫前后细胞命运的规范
作者：
C. Hunter;C. Kenyon
触角类同源框（Hox）基因在脊椎动物、昆虫和线虫中指定连续前后体结构域中的细胞命运1 -3。脊椎动物和果蝇Hox蛋白之间的DNA结合同源结构域序列非常相似，这种相似性允许脊椎动物Hox蛋白在果蝇中发挥功能4 -7。相比之下，秀丽隐杆线虫同源结构域基本上是发散的8。此外，C.秀丽线虫与昆虫和脊椎动物的不同之处在于具有非分节的身体以及独特的发育模式，包括不对称的早期分裂和不变的细胞谱系。在这里，我们报告说，尽管有这些差异，果蝇Hox蛋白表达在C。elegans可以替代C.线虫Hox蛋白在控制三种不同的细胞命运决定中的作用：细胞迁移的调节、神经元的特异性和感觉结构的特异性。我们还表明，一个线虫Hox蛋白的特异性部分是由两个氨基酸序列特异性的DNA结合有牵连。总之，这些发现表明，特定Hox蛋白的靶点识别的重要因素在大多数动物王国中是保守的。
ANTENNAPEDIA class homeobox (Hox) genes specify cell fates in successive anteroposterior body domains in vertebrates, insects and nematodes1-3. The DNA-binding homeodomain sequences are very similar between vertebrate and Drosophila Hox proteins, and this similarity allows vertebrate Hox proteins to function in Drosophila4-7. In contrast, the Caenorhabditis elegans homeodomains are substantially divergent8. Further, C. elegans differs from both insects and vertebrates in having a non-segmented body as well as a distinctive mode of development that involves asymmetric early cleavages and invariant cell lineages. Here we report that, despite these differences, Drosophila Hox proteins expressed in C. elegans can substitute for C. elegans Hox proteins in the control of three different cell-fate decisions: the regulation of cell migra-tion, the specification of serotonergic neurons, and the specification of a sensory structure. We also show that the specificity of one C elegans Hox protein is partly determined by two amino acids that have been implicated in sequence-specific DNA binding. Together these findings suggest that factors important for target recognition by specific Hox proteins have been conserved throughout much of the animal kingdom.
影响因子：
11.4
作者：
MELLO, CC;KRAMER, JM;AMBROS, V
通讯作者：
AMBROS, V
小鼠 Hox-1.3 基因在功能上等同于果蝇性梳减少基因。
影响因子：
10.5
作者：
Zhao,JJ;Lazzarini,RA;Pick,L
通讯作者：
Pick,L