Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer's disease.
Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer's disease.
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DOI：
10.1038/s41598-022-11153-4
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发表时间：
2022-05-05
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
十齿鼠是一种南美啮齿类动物，作为衰老和散发性迟发性阿尔茨海默病(AD)的潜在模型而受到越来越多的关注。已有报道称，Ocdon des的空间记忆任务障碍与晚期AD样疾病或海马区病变有关，这为研究海马区网络功能如何影响AD各阶段的行为开辟了道路。然而，在该物种中不存在海马区电生理学的特征。在这里，我们描述了在有和没有物体的空间导航任务中，年轻、健康的样本中神经元的活动和局部场电位节律。我们的发现表明，奥特登德古斯与实验室啮齿动物有相似之处。首先，具有与大鼠和小鼠相似特征的细胞存在于Ocdon deus的CA1亚区。其次，物体的引入引起了与新奇相关的探索和CA1细胞活动的增加，具有位置特定和非特定成分。第三，局部场势的振荡根据其光谱内容被组织成类似于在实验室啮齿动物中发现的频带。这些结果表明了一个潜在机制的共同框架，为未来研究与衰老和疾病有关的该物种的海马体功能障碍开辟了道路。
The Octodon degus is a South American rodent that is receiving increased attention as a potential model of aging and sporadic late-onset Alzheimer’s disease (AD). Impairments in spatial memory tasks in Octodon degus have been reported in relation to either advanced AD-like disease or hippocampal lesion, opening the way to investigate how the function of hippocampal networks affects behavior across AD stages. However, no characterization of hippocampal electrophysiology exists in this species. Here we describe in young, healthy specimens the activity of neurons and local field potential rhythms during spatial navigation tasks with and without objects. Our findings show similarities between the Octodon degus and laboratory rodents. First, place cells with characteristics similar to those found in rats and mice exist in the CA1 subfield of the Octodon degus. Second, the introduction of objects elicits novelty-related exploration and an increase in activity of CA1 cells, with location specific and unspecific components. Third, oscillations of the local field potential are organized according to their spectral content into bands similar to those found in laboratory rodents. These results suggest a common framework of underlying mechanisms, opening the way to future studies of hippocampal dysfunction in this species associated to aging and disease.
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DOI：
10.1523/jneurosci.5110-11.2012
发表时间：
2012-05-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ahmed OJ;Mehta MR
通讯作者：
Mehta MR
DOI：
10.1073/pnas.1201209109
发表时间：
2012-08-21
影响因子：
11.1
作者：
Ardiles, Alvaro O.;Tapia-Rojas, Cheril C.;Palacios, Adrian G.
通讯作者：
Palacios, Adrian G.
影响因子：
4.2
作者：
Inestrosa, NC;Reyes, AE;Aboitiz, F
通讯作者：
Aboitiz, F
影响因子：
4.8
作者：
Altimiras F;Uszczynska-Ratajczak B;Camara F;Vlasova A;Palumbo E;Newhouse S;Deacon RM;Farias LA;Hurley MJ;Loyola DE;Vásquez RA;Dobson R;Guigó R;Cogram P
通讯作者：
Cogram P
影响因子：
56.9
作者：
Langston, Rosamund F.;Ainge, James A.;Moser, May-Britt
通讯作者：
Moser, May-Britt