Association of MRI T1 relaxation time with neuropsychological test performance in manganese- exposed welders.
Association of MRI T1 relaxation time with neuropsychological test performance in manganese- exposed welders.
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DOI：
10.1016/j.neuro.2017.05.010
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发表时间：
2018-01
期刊：
影响因子：
3.4
通讯作者：
Dydak U
中科院分区：
文献类型：
--
作者：
Bowler RM;Yeh CL;Adams SW;Ward EJ;Ma RE;Dharmadhikari S;Snyder SA;Zauber SE;Wright CW;Dydak U
本研究检查了26名活跃焊工和17名类似对照的神经心理学测试结果及其与焊工的MRI T1弛豫时间缩短的关系，表明脑锰（Mn）积累增加。焊工暴露于锰的平均持续时间为12.25年，空气中锰的平均水平为0.11 ± 0.05 mg/m3。焊工在水果震颤和平行线震颤测试中的得分明显低于对照组。焊工在苍白球、黑质、尾状核和前额叶的MRI T1弛豫时间比对照组短。暴露组占MRI T1弛豫时间变化的63%。在焊工中，尾状核和黑质的较低松弛时间与语言流畅性（Fruit Fluency）、语言学习、记忆和持续性（WHO-UCLA AVLT）测试中较低的神经心理学测试表现相关。结果表明，言语功能可能是第一个认知领域的影响，脑锰沉积在焊工反映的MRI T1弛豫时间。
This study examines the results of neuropsychological testing of 26 active welders and 17 similar controls and their relationship to welders' shortened MRI T1 relaxation time, indicative of increased brain manganese (Mn) accumulation. Welders were exposed to Mn for an average duration of 12.25 years to average levels of Mn in air of 0.11 ± 0.05 mg/m3. Welders scored significantly worse than controls on Fruit Naming and the Parallel Lines test of graphomotor tremor. Welders had shorter MRI T1 relaxation times than controls in the globus pallidus, substantia nigra, caudate nucleus, and the anterior prefrontal lobe. 63% of the variation in MRI T1 relaxation times was accounted for by exposure group. In welders, lower relaxation times in the caudate nucleus and substantia nigra were associated with lower neuropsychological test performance on tests of verbal fluency (Fruit Naming), verbal learning, memory, and perseveration (WHO-UCLA AVLT). Results indicate that verbal function may be one of the first cognitive domains affected by brain Mn deposition in welders as reflected by MRI T1 relaxation times.
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