Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders.
Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders.
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DOI：
10.1136/oemed-2011-100119
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发表时间：
2012-06
影响因子：
4.9
通讯作者：
Racette BA
中科院分区：
文献类型：
--
作者：
Criswell SR;Perlmutter JS;Huang JL;Golchin N;Flores HP;Hobson A;Aschner M;Erikson KM;Checkoway H;Racette BA
锰暴露导致弥漫性脑金属沉积，苍白球中的浓度最高，并伴有T1加权MRI信号增加。尚未研究职业暴露工人的苍白球外基底神经节（尾状核和壳核）的T1信号强度。扩散加权成像是一种非侵入性的神经元损伤的措施，并可以提供与焊接和锰暴露相关的神经毒性的量化。本研究研究了苍白球外T1基底神经节信号强度作为锰暴露的标志物，以及基底神经节扩散加权成像异常作为神经毒性的潜在标志物。对18名焊工和18名年龄和性别匹配的对照者进行了3T MR病例：对照成像研究。确定了每例受试者的基底神经节感兴趣区域。T1加权强度指数和表观扩散系数为每个区域。焊工的所有区域指数均高于对照组（p≤0.05）。基底节（ρ=0.610）、尾状核（ρ=0.645）、前壳核（ρ=0.595）和后壳核（ρ=0.511）指数与暴露的相关性高于苍白球（ρ=0.484）指数。苍白球（p=0.03）和前壳核（p=0.004）的焊工表观扩散系数值低于对照组。焊工表现出升高的T1指数在整个基底神经节。结合基底神经节，尾状核和壳核指数与暴露的相关性比苍白球指数更高，表明更具包容性的基底神经节采样结果更好的暴露标志物。升高的指数与苍白球和前壳核的弥散加权异常相关，表明这些区域存在神经毒性。
Manganese exposure leads to diffuse cerebral metal deposition with the highest concentration in the globus pallidus associated with increased T1-weighted MRI signal. T1 signal intensity in extra-pallidal basal ganglia (caudate and putamen) has not been studied in occupationally exposed workers. Diffusion weighted imaging is a non-invasive measure of neuronal damage and may provide a quantification of neurotoxicity associated with welding and manganese exposure. This study investigated extra-pallidal T1 basal ganglia signal intensity as a marker of manganese exposure and basal ganglia diffusion weighted imaging abnormalities as a potential marker of neurotoxicity. A 3T MR case:control imaging study was performed on 18 welders and 18 age- and gender-matched controls. Basal ganglia regions of interest were identified for each subject. T1-weighted intensity indices and apparent diffusion coefficients were generated for each region. All regional indices were higher in welders than controls (p≤0.05). Combined basal ganglia (ρ=0.610), caudate (ρ=0.645), anterior (ρ=0.595) and posterior putamen (ρ=0.511) indices were more correlated with exposure than pallidal (ρ=0.484) index. Welder apparent diffusion coefficient values were lower than controls for globus pallidus (p=0.03) and anterior putamen (p=0.004). Welders demonstrated elevated T1 indices throughout the basal ganglia. Combined basal ganglia, caudate and putamen indices were more correlated with exposure than pallidal index suggesting more inclusive basal ganglia sampling results in better exposure markers. Elevated indices were associated with diffusion weighted abnormalities in the pallidum and anterior putamen suggesting neurotoxicity in these regions.
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影响因子：
2
作者：
Hobson AJ;Sterling DA;Emo B;Evanoff BA;Sterling CS;Good L;Seixas N;Checkoway H;Racette BA
通讯作者：
Racette BA
影响因子：
4.4
作者：
LARSEN N A;PAKKENBERG H;HEYDORN K
通讯作者：
HEYDORN K
影响因子：
3.4
作者：
Kim, Yangho;Jeong, Kyoung Sook;Chang, Yongmin
通讯作者：
Chang, Yongmin
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
6.1
作者：
ERIKSSON, H;MAGISTE, K;HEILBRONN, E
通讯作者：
HEILBRONN, E