Novel serine proteases encoded by two cytotoxic T lymphocyte-specific genes.
Novel serine proteases encoded by two cytotoxic T lymphocyte-specific genes.
复制标题
由两个细胞毒性 T 淋巴细胞特异性基因编码的新型丝氨酸蛋白酶。
作者：
C. Lobe;B. Finlay;W. Paranchych;V. Paetkau;R. Bleackley
仅在细胞毒性T细胞中表达的基因应该编码在细胞介导的免疫反应中对靶细胞裂解至关重要的蛋白质。两个细胞毒性T淋巴细胞特异性互补DNA(CDNAs)的序列表明这两个基因编码丝氨酸蛋白酶。对其中一个基因的全长cDNA进行了分离和测序。预测的蛋白质与丝氨酸蛋白酶相似，因为它包括形成丝氨酸蛋白酶活性部位的催化三联体的所有残基。此外，它还具有被认为只存在于大鼠肥大细胞蛋白酶II中的序列特征。这些结果与蛋白酶级联在细胞毒性T细胞激活中起关键作用的观点是一致的。
Genes that are expressed exclusively in cytotoxic T cells should encode proteins that are essential for target cell lysis in cell-mediated immune responses. The sequences of two cytotoxic T lymphocyte-specific complementary DNA's (cDNA's) suggest that the two genes encode serine proteases. A full-length cDNA corresponding to one of the genes was isolated and sequenced. The predicted protein resembles serine proteases in that it includes all the residues that form the catalytic triad of the active site of serine proteases. Moreover, it has sequence characteristics thought to occur only in rat mast cell protease type II. These results are in accord with the view that a protease cascade plays a key role in cytotoxic T-cell activation.
影响因子：
2.9
作者：
Powers,JC;Tanaka,T;Harper,JW;Minematsu,Y;Barker,L;Lincoln,D;Crumley,KV;Fraki,JE;Schechter,NM;Lazarus,GG
通讯作者：
Lazarus,GG