Epilepsy in Neurodegenerative Diseases: Related Drugs and Molecular Pathways.
Epilepsy in Neurodegenerative Diseases: Related Drugs and Molecular Pathways.
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癫痫在神经退行性疾病：相关药物和分子途径。
DOI：
10.3390/ph14101057
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发表时间：
2021-10-18
期刊：
影响因子：
--
通讯作者：
Ruíz A
中科院分区：
文献类型：
--
作者：
Cano A;Fonseca E;Ettcheto M;Sánchez-López E;de Rojas I;Alonso-Lana S;Morató X;Souto EB;Toledo M;Boada M;Marquié M;Ruíz A
癫痫是一种以神经元电失衡为特征的慢性中枢神经系统疾病。它是第二种最常见的神经系统疾病，全世界有5000万人受到影响，30%的癫痫患者对现有的治疗方法没有反应。目前，关于触发癫痫发作的分子过程和促进导致细胞死亡的神经毒性效应的主要假说集中在谷氨酸途径的加剧和不同因素导致的钙离子大量内流。然而，已经提出了其他机制，其中大多数也被描述在其他神经退行性疾病中，如阿尔茨海默病、帕金森氏病、亨廷顿病或多发性硬化症。有趣的是，主要是因为这些共同的分子联系以及对这些疾病缺乏有效的治疗，一些抗癫痫药物已经被研究，以评估它们在这些病理中的治疗潜力。因此，在本综述中，我们深入研究癫痫与主要神经退行性疾病之间的共同分子通路，检测癫痫在这些人群中的发病率，并探索当前和创新的抗癫痫药物在治疗难治性癫痫和其他神经退行性疾病中的应用。
Epilepsy is a chronic disease of the central nervous system characterized by an electrical imbalance in neurons. It is the second most prevalent neurological disease, with 50 million people affected around the world, and 30% of all epilepsies do not respond to available treatments. Currently, the main hypothesis about the molecular processes that trigger epileptic seizures and promote the neurotoxic effects that lead to cell death focuses on the exacerbation of the glutamate pathway and the massive influx of Ca2+ into neurons by different factors. However, other mechanisms have been proposed, and most of them have also been described in other neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, or multiple sclerosis. Interestingly, and mainly because of these common molecular links and the lack of effective treatments for these diseases, some antiseizure drugs have been investigated to evaluate their therapeutic potential in these pathologies. Therefore, in this review, we thoroughly investigate the common molecular pathways between epilepsy and the major neurodegenerative diseases, examine the incidence of epilepsy in these populations, and explore the use of current and innovative antiseizure drugs in the treatment of refractory epilepsy and other neurodegenerative diseases.
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影响因子：
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通讯作者：
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