Is sensitization to pig antigens detrimental to subsequent allotransplantation?
Is sensitization to pig antigens detrimental to subsequent allotransplantation?
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DOI：
10.1111/xen.12393
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发表时间：
2018-05
影响因子：
3.9
通讯作者：
Cooper DKC
中科院分区：
文献类型：
--
作者：
Li Q;Hara H;Zhang Z;Breimer ME;Wang Y;Cooper DKC
异种移植的一个重要问题是，对猪异种移植物过敏的患者是否可以安全地进行同种异体移植。为了回答这个问题，我们查阅了文献。我们主要将回顾限制在与临床相关的猪-非人灵长类动物（NHP）模型上，并发现了五项探讨该主题的研究。接受猪移植的NHP没有产生针对同种异体抗原的抗体，体外研究表明没有增加体液和/或细胞的同种异体反应性。我们自己进行了一项小型体外研究，证实了这一结论。有3个透析患者暴露于野生型猪肾的实验，以及3个肝功能衰竭患者桥接到同种异体肝移植的临床研究。尽管出现了抗猪抗体，所有随后的器官（肾或肝）异体移植都是成功的（可能只有一个病例除外）。此外，还将猪胎儿胰岛移植到同种异体肾移植患者体内；整体反应性同种异体抗体没有增加，肾移植物继续发挥令人满意的功能。总之，有限的数据表明，在猪抗原致敏后，没有证据表明抗体介导或加速了随后的同种异体移植物的细胞排斥反应。
An important question in xenotransplantation is whether an allotransplant can safely be carried out in a patient who has become sensitized to a pig xenograft. To answer this question, we have searched the literature. We primarily limited our review to the clinically-relevant pig-to nonhuman primate (NHP) model, and found five studies that explored this topic. No NHP that had received a pig graft developed antibodies to alloantigens, and in vitro studies indicated no increased humoral and/or cellular alloreactivity. We carried out a small in vitro study ourselves that confirmed this conclusion. There have been three experiments in which patients undergoing dialysis were exposed to wild-type pig kidneys, and three clinical studies related to bridging a patient in hepatic failure to liver allotransplantation. Despite the development of anti-pig antibodies, all subsequent organ (kidney or liver) allografts were successful (except possibly in one case). In addition, pig fetal islets were transplanted into patients with kidney allografts; there was no increase in panel-reactive allo-antibodies and the kidney grafts continued to function satisfactorily. In conclusion, the limited data suggest that, after sensitization to pig antigens, there is no evidence of antibody-mediated or accelerated cellular rejection of a subsequent allograft.
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DOI：
10.1007/s005340070030
发表时间：
2000-01-01
期刊：
Journal of hepato-biliary-pancreatic surgery
影响因子：
--
作者：
Groth, C G;Tibell, A;Korsgren, O
通讯作者：
Korsgren, O
影响因子：
3.9
作者：
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通讯作者：
Cooper, David K. C.
影响因子：
3.9
作者：
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通讯作者：
Cosimi, A
影响因子：
4.4
作者：
CAIRNS, TDH;TAUBE, DH;WELSH, KI
通讯作者：
WELSH, KI
DOI：
10.1016/s0022-5223(96)70101-0
发表时间：
1996-10-01
影响因子：
6
作者：
Michler, RE;Shah, AS;SuciuFoca, N
通讯作者：
SuciuFoca, N