Diversity of Macrophages in Lung Homeostasis and Diseases.
Diversity of Macrophages in Lung Homeostasis and Diseases.
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DOI：
10.3389/fimmu.2021.753940
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发表时间：
2021
影响因子：
7.3
通讯作者：
Xie L
中科院分区：
文献类型：
--
作者：
Hou F;Xiao K;Tang L;Xie L
肺巨噬细胞在维持机体内环境稳定、清除病原体和免疫调节等方面发挥重要作用。近年来，不同类型的肺巨噬细胞及其在肺部疾病中的作用引起了人们的关注。肺泡巨噬细胞（AM），包括组织驻留肺泡巨噬细胞（TR-AM）和单核细胞衍生的肺泡巨噬细胞（Mo-AM），以及间质巨噬细胞（IM）是肺中的主要巨噬细胞群体，在稳态条件和疾病状态下都具有独特的特征。这三种类型的巨噬细胞的不同特性决定了它们在疾病发展中发挥的不同作用。因此，充分了解这三种类型的巨噬细胞之间的异同对于肺部疾病的研究至关重要。本文就这三种巨噬细胞的生理特性及其在急慢性肺部疾病中的独特功能作一综述。我们还将讨论在肺部疾病中靶向巨噬细胞的可能方法。
Lung macrophages play important roles in the maintenance of homeostasis, pathogen clearance and immune regulation. The different types of pulmonary macrophages and their roles in lung diseases have attracted attention in recent years. Alveolar macrophages (AMs), including tissue-resident alveolar macrophages (TR-AMs) and monocyte-derived alveolar macrophages (Mo-AMs), as well as interstitial macrophages (IMs) are the major macrophage populations in the lung and have unique characteristics in both steady-state conditions and disease states. The different characteristics of these three types of macrophages determine the different roles they play in the development of disease. Therefore, it is important to fully understand the similarities and differences among these three types of macrophages for the study of lung diseases. In this review, we will discuss the physiological characteristics and unique functions of these three types of macrophages in acute and chronic lung diseases. We will also discuss possible methods to target macrophages in lung diseases.
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