Respiratory viral sepsis: epidemiology, pathophysiology, diagnosis and treatment.
Respiratory viral sepsis: epidemiology, pathophysiology, diagnosis and treatment.
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呼吸道病毒败血症：流行病学，病理生理学，诊断和治疗。
DOI：
10.1183/16000617.0038-2020
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发表时间：
2020-09-30
影响因子：
7.5
通讯作者：
Cao, Bin
中科院分区：
文献类型：
--
作者：
Gu, Xiaoying;Zhou, Fei;Wang, Yeming;Fan, Guohui;Cao, Bin
根据脓毒症和脓毒性休克的第三次国际共识定义，脓毒症是由宿主对感染的反应失调引起的危及生命的器官功能障碍。2017年全球疾病、伤害和风险因素负担研究中关于脓毒症的流行病学数据显示，脓毒症的全球负担大于先前的估计。在检测到病原体的患者中，细菌已被证明是脓毒症的主要病原体，而病毒引起的脓毒症在世界范围内诊断不足。2019年在中国出现的冠状病毒病以及现在在许多其他国家出现的冠状病毒病使病毒性败血症重新回到了全球医生和研究人员的视野。虽然目前对脓毒症的病理生理学的理解已经有所改善，但病毒性脓毒症和细菌性脓毒症在病理生理学水平上的差异还没有得到很好的理解。在脓毒症发展后的初始阶段，可以广泛区分细菌性脓毒症和病毒性脓毒症的诊断方法是有限的。新的治疗方法，可以应用在临床败血症是稀缺的，这种情况是不符合不断增长的理解的病理生理学。本文就病毒性脓毒症的流行病学、病理生理学、诊断和治疗等方面的研究进展作一综述。病毒性败血症的疾病负担很大。虽然目前对脓毒症的认识有所提高，但病毒性脓毒症和细菌性脓毒症之间的差异尚未得到很好的理解。呼吸道病毒性脓毒症亟待引起重视。https://bit.ly/2Vujpfl
According to the Third International Consensus Definition for Sepsis and Septic Shock, sepsis is a life-threatening organ dysfunction resulting from dysregulated host responses to infection. Epidemiological data about sepsis from the 2017 Global Burden of Diseases, Injuries and Risk Factor Study showed that the global burden of sepsis was greater than previously estimated. Bacteria have been shown to be the predominant pathogen of sepsis among patients with pathogens detected, while sepsis caused by viruses is underdiagnosed worldwide. The coronavirus disease that emerged in 2019 in China and now in many other countries has brought viral sepsis back into the vision of physicians and researchers worldwide. Although the current understanding of the pathophysiology of sepsis has improved, the differences between viral and bacterial sepsis at the level of pathophysiology are not well understood. Diagnosis methods that can broadly differentiate between bacterial and viral sepsis at the initial stage after the development of sepsis are limited. New treatments that can be applied at clinics for sepsis are scarce and this situation is not consistent with the growing understanding of pathophysiology. This review aims to give a brief summary of current knowledge of the epidemiology, pathophysiology, diagnosis and treatment of viral sepsis. The disease burden of sepsis from viruses is great. Although current understanding of sepsis has improved, the differences between viral and bacterial sepsis were not well understood. It is urgent to pay more attention to respiratory viral sepsis. https://bit.ly/2Vujpfl
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影响因子：
120.7
作者：
Boomer, Jonathan S.;To, Kathleen;Chang, Kathy C.;Takasu, Osamu;Osborne, Dale F.;Walton, Andrew H.;Bricker, Traci L.;Jarman, Stephen D., II;Kreisel, Daniel;Krupnick, Alexander S.;Srivastava, Anil;Swanson, Paul E.;Green, Jonathan M.;Hotchkiss, Richard S.
通讯作者：
Hotchkiss, Richard S.
影响因子：
10
作者：
Cilloniz, Catia;Ewig, Santiago;Torres, Antoni
通讯作者：
Torres, Antoni
影响因子：
6.7
作者：
de Stoppelaar, Sacha F.;van 't Veer, Cornelis;van der Poll, Tom
通讯作者：
van der Poll, Tom
影响因子：
6.4
作者：
Cilloniz, Catia;Dominedo, Cristina;Torres, Antoni
通讯作者：
Torres, Antoni
DOI：
10.1016/s1473-3099(13)70154-3
发表时间：
2013-09
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Drosten C;Seilmaier M;Corman VM;Hartmann W;Scheible G;Sack S;Guggemos W;Kallies R;Muth D;Junglen S;Müller MA;Haas W;Guberina H;Röhnisch T;Schmid-Wendtner M;Aldabbagh S;Dittmer U;Gold H;Graf P;Bonin F;Rambaut A;Wendtner CM
通讯作者：
Wendtner CM