Structural and functional imaging markers for susceptibility to psychosis.

Structural and functional imaging markers for susceptibility to psychosis.
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DOI:
10.1038/s41380-020-0679-7
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发表时间:
2020-11
影响因子:
11
通讯作者:
Borgwardt S
Borgwardt S
中科院分区:
医学1区
文献类型:
--
作者:
Andreou C;Borgwardt S

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精神病高风险实施临床标准的引入为弱势个体的早期发现和治疗提供了基础。然而,大约三分之二符合临床高风险(CHR)标准的人永远不会患上精神障碍。为了提高预后精度,结构和功能神经影像学作为预测 CHR 患者精神病转变的潜在有用资源受到越来越多的关注。本综述总结了当前 CHR 状态神经影像生物标志物的研究,特别关注其预后效用和局限性。需要进行大型、多模式/多中心研究来解决对临床适用性重要的问题,例如普遍性和可重复性、临床定义和神经影像方法的标准化以及对背景因素(例如年龄、合并症)的考虑。
The introduction of clinical criteria for the operationalization of psychosis high risk provided a basis for early detection and treatment of vulnerable individuals. However, about two-thirds of people meeting clinical high-risk (CHR) criteria will never develop a psychotic disorder. In the effort to increase prognostic precision, structural and functional neuroimaging have received growing attention as a potentially useful resource in the prediction of psychotic transition in CHR patients. The present review summarizes current research on neuroimaging biomarkers in the CHR state, with a particular focus on their prognostic utility and limitations. Large, multimodal/multicenter studies are warranted to address issues important for clinical applicability such as generalizability and replicability, standardization of clinical definitions and neuroimaging methods, and consideration of contextual factors (e.g., age, comorbidity).
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