Atrial natriuretic peptide during supraventricular tachycardia and relation to hemodynamic changes and renal function.
Atrial natriuretic peptide during supraventricular tachycardia and relation to hemodynamic changes and renal function.
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室上性心动过速期间的心房钠尿肽及其与血流动力学变化和肾功能的关系。
DOI：
10.1016/0002-9149(88)91166-6
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发表时间：
1988
影响因子：
2.8
通讯作者：
Wu Delon
中科院分区：
文献类型：
--
作者：
Tsai Rong;Yamaji Tohru;Ishibashi Miyuki;Takaku Fumimaro;Pang Siu;Yeh San;Lee Ying;Hung Jui;Wu Delon
本文观察了5例诱导性室上性心动过速(SVT)患者血浆心钠素(ANP)和精氨酸加压素(ARP)水平的变化。诱发SVT后即刻，血浆ANP水平开始升高，32min达高峰(平均增加734%)，随后逐渐下降。SVT期间血浆精氨酸加压素平均水平下降，但差异无统计学意义。将心钠素水平与同步测定的血流动力学指标进行比较，发现血浆心钠素水平与肺毛细血管楔压呈显著正相关(r=0.73p<；0.001)。诱发性室上性心动过速与尿钠、钾排泄增加、尿流量增加和游离水清除增加有关。同时，随着滤过分数的增加，肾小球滤过率显著增加(+77%)。虽然血浆肾素活性没有明显变化，但血浆醛固酮浓度在SVT期间和术后下降。这些结果提示，SVT时左心房压力升高刺激ANP释放，ANP增加肾小球滤过率和减少醛固酮分泌，以及精氨酸加压素减少抑制水重吸收，可能与SVT相关的利钠和利尿有关。
Changes in plasma levels of atrial natriuretic peptide (ANP) and arginine vasopressin were studied in 5 patients during and after a 30-minute period of induced supraventricular tachycardia (SVT). Immediately after the induction of SVT, plasma ANP levels began to increase, peaked at 32 minutes (+734% increase on average) and then gradually decreased. The mean plasma arginine vasopressin levels decreased during SVT, but the differences were not significant. When plasma ANP levels during SVT were compared with the simultaneously measured hemodynamic variables, a significant positive correlation (r = 0.73, p < 0.001) was observed between plasma ANP levels and pulmonary capillary wedge pressure. Induced SVT was associated with increased urinary sodium and potassium excretion, increased urine flow and increased free water clearance. Concomitantly, glomerular filtration rate significantly increased (+77%) with an increase in filtration fraction. Although no significant change was observed in plasma renin activity, plasma aldosterone concentrations decreased during and after SVT. These results suggest that increased left atrial pressure stimulates ANP release during SVT and that increased glomerular filtration rate and decreased aldosterone secretion by ANP, in addition to the inhibition of water reabsorption by decreased arginine vasopressin, may be responsible for natriuresis and diuresis associated with SVT.
人体免疫反应性心房钠尿激素血浆水平与血流动力学功能之间的关系。
影响因子：
37.8
作者：
Bates,ER;Shenker,Y;Grekin,RJ
通讯作者：
Grekin,RJ