CalDAG-GEFI and platelet activation.

CalDAG-GEFI and platelet activation.
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CalDAG-GEFI 和血小板活化。

DOI:
10.3109/09537101003639931
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发表时间:
2010
期刊:
影响因子:
3.3
通讯作者:
Bergmeier W
Bergmeier W
中科院分区:
医学3区
文献类型:
--
作者:
Stefanini L;Bergmeier W

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Rapid activation of platelets at sites of vascular injury is a critical event in thrombosis and hemostasis. Here, we review recent findings, which a) identified CalDAG-GEFI (RasGRP2) at the nexus of the rapid, Ca2+-dependent platelet activation, b) demonstrated a complex synergy between signaling provided by CalDAG-GEFI, protein kinase C, and the Gi-coupled receptor for ADP, P2Y12, and c) suggested CalDAG-GEFI as a novel target for anti-platelet therapy.
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