Association between big endothelin-1 and CHADS2/CHA2DS2-VASc scores in non-valvular atrial fibrillation
Association between big endothelin-1 and CHADS2/CHA2DS2-VASc scores in non-valvular atrial fibrillation
复制标题
非瓣膜性心房颤动中大内皮素-1 与 CHADS2/CHA2DS2-VASc 评分之间的关联
DOI：
10.11909/j.issn.1671-5411.2019.11.003
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Yan Yao
中科院分区：
文献类型：
--
作者：
Lihui Zheng;Shangyu Liu;Feng Hu;E. Liang;Ling;Hong;A. Killu;Yan Yao
背景内皮功能，如大内皮素-1（ET-1）的测量，已被证明是有用的预测心血管疾病患者的不良长期事件。然而，关于大ET-1与心房颤动（AF）血栓栓塞风险之间的关系的数据很少。我们的目的是探讨大ET-1和CHADS 2/CHA 2DS 2-VASc评分用于评估血栓栓塞风险的非瓣膜性AF患者。方法研究人群包括238例连续AF患者（67.6%阵发性AF和32.4%持续性AF）。根据CHADS 2和CHA 2DS 2-VASc评分（评分分别≥ 2或< 2）将患者分为两组（高风险组或低-中风险组）。对临床、实验室和超声心动图参数进行了评价，并对两组之间的CHADS 2/CHA 2DS 2-VASc评分进行了比较。评估大ET-1水平与CHADS 2/CHA 2DS 2-VASc评分的相关性。进行多变量logistic回归分析以确定CHADS 2/CHA 2DS 2-VASc评分的独立预测因素。结果CHADS 2/CHA 2DS 2-VASc评分高组患者年龄大、血浆ET-1水平高、左房内径大，与CHADS 2/CHA 2DS 2-VASc评分低组比较，差异有统计学意义（P < 0.05）。多因素Logistic回归分析显示，ET-1水平升高是CHADS 2/CHA 2DS 2-VASc评分升高的独立危险因素[OR = 2.545和OR = 3.816，均P < 0.05]。结论在非瓣膜性房颤患者中，ET-1与CHADS 2/CHA 2DS 2-VASc评分显著相关，是CHADS 2/CHA 2DS 2-VASc评分增高的独立预测因子。在这种情况下，大ET-1可能作为危险分层的有用标志物。
Background Endothelial function, as measured by big endothelin-1 (ET-1), has been demonstrated to be useful in predicting adverse long-term events in patients with cardiovascular disease. Nevertheless, there are little data about the association between big ET-1 and thromboembolism risk in atrial fibrillation (AF). We aimed to investigate the relationship between big ET-1 and CHADS2/CHA2DS2-VASc scores used for evaluating thromboembolic risk in patients with non-valvular AF. Methods The study population consisted of 238 consecutive AF patients (67.6% with paroxysmal AF and 32.4% with persistent AF). The patients were divided into two groups (high- or low-intermediate risk group) based on CHADS2 and CHA2DS2-VASc scores (score ≥ 2 or < 2, respectively). Clinical, laboratory, and echocardiographic parameters were evaluated, and the CHADS2/CHA2DS2-VASc scores were compared between groups. The association between big ET-1 levels and CHADS2/CHA2DS2-VASc score was assessed. Multivariate logistic regression analysis was performed to identify independent predictors of CHADS2/CHA2DS2-VASc scores. Results The high CHADS2/CHA2DS2-VASc score group had older age, higher big ET-1 levels, and enlarged left atrial diameter than the low CHADS2/CHA2DS2-VASc score group (P < 0.05). Multiple logistic regression analysis revealed that big ET-1 level was an independent determinant of high CHADS2/CHA2DS2-VASc scores [odds ratio (OR) = 2.545 and OR = 3.816; both P < 0.05]. Conclusions Our study indicates that in non-valvular AF, big ET-1 was significantly correlated with CHADS2/CHA2DS2-VASc scores and an independent predictor of high CHADS2/CHA2DS2-VASc scores. Big ET-1 may serve as a useful marker for risk stratification in this setting.
登录
查看更多内容
DOI：
10.1016/s1062-1458(01)00458-5
发表时间：
2001-11
期刊：
JAMA
影响因子：
--
作者：
B. Gage;A. Waterman;W. Shannon;M. Boechler;M. Rich;M. Radford
通讯作者：
B. Gage;A. Waterman;W. Shannon;M. Boechler;M. Rich;M. Radford
影响因子：
2.8
作者：
Chamberlain, Alanna M.;Agarwal, Sunil K.;Folsom, Aaron R.;Soliman, Elsayed Z.;Chambless, Lloyd E.;Crow, Richard;Ambrose, Marietta;Alonso, Alvaro
通讯作者：
Alonso, Alvaro
影响因子：
120.7
作者：
Wang, TJ;Massaro, JM;Benjamin, EJ
通讯作者：
Benjamin, EJ
影响因子：
24
作者：
Lindman, Brian R.;Davila-Roman, Victor G.;Mann, Douglas L.;McNulty, Steven;Semigran, Marc J.;Lewis, Gregory D.;de las Fuentes, Lisa;Joseph, Susan M.;Vader, Justin;Hernandez, Adrian F.;Redfield, Margaret M.
通讯作者：
Redfield, Margaret M.
影响因子：
120.7
作者：
Go, AS;Hylek, EM;Singer, DE
通讯作者：
Singer, DE