Tumour dormancy in breast cancer: an update.

Tumour dormancy in breast cancer: an update.
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DOI:
10.1186/bcr1677
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发表时间:
2007
期刊:
Breast cancer research : BCR
影响因子:
--
通讯作者:
Chambers AF
Chambers AF
中科院分区:
其他
文献类型:
--
作者:
Brackstone M;Townson JL;Chambers AF

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延迟复发,常见于乳腺癌,是很好地解释了肿瘤休眠的概念。许多出版物描述了疾病复发或死亡的临床时间,使用数学方法来推断延迟复发的机制。然而,大多数讨论肿瘤休眠的临床文献使用了半个多世纪前的数据,此后发生了很大变化。这篇综述探讨了目前的乳腺癌治疗如何改变我们对乳腺癌肿瘤休眠生物学的理解,并总结了迄今为止的相关实验模型。目前的知识差距突出,并确定了未来研究的潜在领域。
Delayed recurrences, common in breast cancer, are well explained by the concept of tumour dormancy. Numerous publications describe clinical times to disease recurrence or death, using mathematical approaches to infer mechanisms responsible for delayed recurrences. However, most of the clinical literature discussing tumour dormancy uses data from over a half century ago and much has since changed. This review explores how current breast cancer treatment could change our understanding of the biology of breast cancer tumour dormancy, and summarizes relevant experimental models to date. Current knowledge gaps are highlighted and potential areas of future research are identified.
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