Assessment of a combination of Serum Proteins as potential biomarkers to clinically predict Schizophrenia.
Assessment of a combination of Serum Proteins as potential biomarkers to clinically predict Schizophrenia.
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评估血清蛋白组合作为临床预测精神分裂症的潜在生物标志物
DOI：
10.7150/ijms.24346
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发表时间：
2018
影响因子：
3.6
通讯作者：
Tang A
中科院分区：
文献类型：
--
作者：
Li C;Tao H;Yang X;Zhang X;Liu Y;Tang Y;Tang A
精神分裂症（SZ）是一种毁灭性的精神疾病。首发精神病 (FEP) 期间潜在血清生物标志物的验证特别有助于了解这种疾病的发病和预后。为了解决这个问题，我们检查了多种血液生物标志物并评估了诊断 SZ 的功效。采用酶联免疫吸附法（ELISA）测定53例FEP患者和57例健康对照外周血中神经调节蛋白1（NRG1）、ErbB4、脑源性神经营养因子（BDNF）、DNA甲基转移酶1（DNMT1）和十十一易位1（TET1）蛋白的表达水平。使用包括生物标志物浓度作为协变量的多变量逻辑回归来预测 SZ。通过接受者操作特征（ROC）曲线分析来分析这五种血清蛋白水平的区分性能。我们发现，与对照组相比，SZ 患者外周血中 DNMT1 和 TET1 的浓度较高，但 NRG1、ErbB4 和 BDNF 的浓度较低。多变量逻辑回归显示，ErbB4、BDNF 和 TET1 是 SZ 的独立预测因子，当组合起来时，可以为 SZ 提供较高的诊断准确性。总之，我们的研究结果强调，NRG1、ErbB4、BDNF、DNMT1 和 TET1 表达的改变与精神分裂症的发展有关，它们可能作为诊断精神分裂症的潜在生物标志物。因此，我们的研究提供了证据，证明 ErbB4、BDNF 和 TET1 生物标志物的组合可以极大地提高诊断性能。
Schizophrenia (SZ) is a devastating psychiatric disorder. Validation of potential serum biomarkers during first-episode psychosis (FEP) is especially helpful to understand the onset and prognosis of this disorder. To address this question, we examined multiple blood biomarkers and assessed the efficacy to diagnose SZ. The expression levels of Neuregulin1 (NRG1), ErbB4, brain-derived neurotrophic factor (BDNF), DNA methyltransferases 1 (DNMT1) and ten-eleven translocation 1 (TET1) proteins in peripheral blood of 53 FEP patients and 57 healthy controls were determined by enzyme-linked immunosorbent assay (ELISA). Multivariable logistic regression including biomarker concentration as covariates was used to predict SZ. Differentiating performance of these five serum protein levels was analyzed by Receiver Operating Characteristic (ROC) curve analysis. We found that patients with SZ present a higher concentration of DNMT1, and TET1 in peripheral blood, but a lower concentration of NRG1, ErbB4 and BDNF than controls. Multivariable logistic regression showed that ErbB4, BDNF and TET1 were independent predictors of SZ, and when combined, provided high diagnostic accuracy for SZ. Together, our findings highlight that altered expression of NRG1, ErbB4, BDNF, DNMT1 and TET1 are involved in schizophrenia development and they may serve as potential biomarkers for the diagnosis of the schizophrenia. Therefore, our study provides evidence that combination of ErbB4, BDNF and TET1 biomarkers could greatly improve the diagnostic performance.
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影响因子：
6.1
作者：
Sotiropoulou, Marianthi;Mantas, Christos;Antoniou, Katerina
通讯作者：
Antoniou, Katerina
影响因子：
11.3
作者：
Niitsu, Tomihisa;Ishima, Tamaki;Iyo, Masaomi
通讯作者：
Iyo, Masaomi
影响因子：
82.9
作者：
Pitcher, Graham M.;Kalia, Lorraine V.;Salter, Michael W.
通讯作者：
Salter, Michael W.
影响因子：
3.8
作者：
Banerjee A;Macdonald ML;Borgmann-Winter KE;Hahn CG
通讯作者：
Hahn CG
影响因子：
10.6
作者：
Roth, Tania L.;Lubin, Farah D.;Funk, Adam J.;Sweatt, J. David
通讯作者：
Sweatt, J. David