Mixed genotypes of Orientia tsutsugamushi in conserved genes and a single immune-dominant tsa56 genotype discovered from a patient with scrub typhus in Hainan Island, China: a case report.
Mixed genotypes of Orientia tsutsugamushi in conserved genes and a single immune-dominant tsa56 genotype discovered from a patient with scrub typhus in Hainan Island, China: a case report.
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中国海南岛恙虫病患者中发现恙虫病东方体保守基因的混合基因型和单一免疫显性 tsa56 基因型：病例报告
DOI：
10.1186/s12879-022-07682-y
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发表时间：
2022-08-19
影响因子：
3.7
通讯作者：
Yin, Feifei
中科院分区：
文献类型：
--
作者：
Tang, Chuanning;Zhang, Liyuan;Huang, Yi;Mai, Wenhui;Xue, Liying;Wang, Gaoyu;Wen, Shu;Peng, Ruoyan;Wu, Kunliang;Tian, Xiuying;Pei, Hua;Du, Jiang;Yuen, Kwok-Yung;Chan, Jasper Fuk-Woo;Du, Yongguo;Yin, Feifei
恙虫病东方体（O.恙虫病是一种专性细胞内细菌，通过受感染的恙螨幼虫叮咬传播给人类，引起恙虫病。混合基因型O.典型保守基因中的恙虫病在8-25%的患者血液样本中报告。然而，很少有临床描述这些混合O。感染恙虫病的病人。我们报告一例恙虫病并发肺部受累和肝功能障碍的患者，其携带保守基因的混合基因型，但具有单一的免疫显性56 kDa型特异性抗原（tsa 56）基因型。该患者通过强力霉素治疗成功恢复。在该报告的病例中，患者的焦痂和血液样本均反复显示相同的结果，即，在具有多个高变区的TSA 56基因中未发现变异。而所选的高度保守基因在2700个碱基对的串联序列中鉴定出多达32个变体。这些单一tsa 56基因型混合感染的患病率、疾病严重程度和发病机制有待于更多病例的大规模调查。在线版本包含补充材料，可通过10.1186/s12879-022-07682-y获得。
Orientia tsutsugamushi (O. tsutsugamushi), an obligate intracellular bacterium, is transmitted to humans through infected larval trombiculid mite bites, causing scrub typhus. Mixed genotypes of O. tsutsugamushi in canonical conserved genes were reported in 8–25% of blood samples from patients. Yet, there are few clinical descriptions of these mixed O. tsutsugamushi-infected patients. We report a patient with scrub typhus complicated with pulmonary involvement and hepatic dysfunction, who carried mixed genotypes of the conserved genes but had a single immune-dominant 56-kDa type-specific antigen (tsa56) genotype. The patient was successfully recovered by doxycycline treatment. In this reported case, both patient’s eschar and blood samples have repeatedly shown the same results, i.e., no variants were discovered in tsa56 gene that bears multiple hypervariable regions. Whereas the selected highly conserved genes were identified with up to 32 variants in a 2700 base-pair concatenated sequence. The prevalence, disease severity and mechanism of these single-tsa56-genotype mixed infections remain to be investigated on a large scale with more cases. The online version contains supplementary material available at 10.1186/s12879-022-07682-y.
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影响因子：
3.8
作者：
Sonthayanon P;Peacock SJ;Chierakul W;Wuthiekanun V;Blacksell SD;Holden MT;Bentley SD;Feil EJ;Day NP
通讯作者：
Day NP
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影响因子：
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影响因子：
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作者：
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通讯作者：
Stenos, John
影响因子：
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作者：
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