A lifecourse Mendelian randomization study uncovers age-dependent effects of adiposity on asthma risk.
A lifecourse Mendelian randomization study uncovers age-dependent effects of adiposity on asthma risk.
复制标题
一项生命周期孟德尔随机研究揭示了肥胖对哮喘风险的年龄依赖性影响。
DOI：
10.1016/j.isci.2023.108356
复制
发表时间：
2023-12-15
期刊：
影响因子：
5.8
通讯作者：
Richardson, Tom G.
中科院分区：
文献类型：
--
作者：
Urquijo, Helena;Leyden, Genevieve M.;Smith, George Davey;Richardson, Tom G.
评估儿童生活方式因素对哮喘风险的长期影响在流行病学中可能是非常具有挑战性的，因为病例通常在整个生命过程的不同时间点被诊断出来。在这项研究中，我们使用人类遗传数据来评估儿童和成人肥胖对儿童（n = 13，962例）和成人发作哮喘（n = 26，582例）风险的影响，并使用称为生命周期孟德尔随机化的技术进行一组常见的对照组（n = 300，671）。我们发现，儿童肥胖直接增加儿童哮喘的风险（OR = 1.20，95%CI = 1.03-1.37，p = 0.03），但有限的证据表明，它对成人发病的哮喘后，在考虑到成年肥胖（OR = 1.05，95%CI = 0.93-1.17，p = 0.39）。相反，有强有力的证据表明，成年肥胖会增加中年哮喘的风险（OR = 1.37，95%CI = 1.28-1.46，P = 7 × 10−12）。这些发现表明，儿童期和成年期肥胖在生命过程中的每个相应时间点都是哮喘的独立危险因素。肥胖是哮喘的一个已知的危险因素哮喘病例可以在整个生命过程中的不同时间点被诊断出来我们使用人类遗传学来解开肥胖对哮喘风险的生命过程影响证据表明儿童肥胖直接增加儿童哮喘的风险独立于这种影响，成年肥胖增加成人发作哮喘的风险健康科学;呼吸医学;儿科
Evaluating the long-term consequences of childhood lifestyle factors on asthma risk can be exceptionally challenging in epidemiology given that cases are typically diagnosed at various timepoints throughout the lifecourse. In this study, we used human genetic data to evaluate the effects of childhood and adulthood adiposity on risk of pediatric (n = 13,962 cases) and adult-onset asthma (n = 26,582 cases) with a common set of controls (n = 300,671) using a technique known as lifecourse Mendelian randomization. We found that childhood adiposity directly increases risk of pediatric asthma (OR = 1.20, 95% CI = 1.03–1.37, p = 0.03), but limited evidence that it has an effect on adult-onset asthma after accounting for adiposity during adulthood (OR = 1.05, 95% CI = 0.93–1.17, p = 0.39). Conversely, there was strong evidence that adulthood adiposity increases asthma risk in midlife (OR = 1.37, 95% CI = 1.28–1.46, P = 7 × 10−12). These findings suggest that childhood and adulthood adiposity are independent risk factors for asthma at each of their corresponding timepoints in the lifecourse. Adiposity is a known risk factor for asthma Cases of asthma can be diagnosed at various timepoints throughout the lifecourse We used human genetics to disentangle lifecourse effects of adiposity on asthma risk Evidence suggested that childhood adiposity directly increases risk of pediatric asthma Independent of this effect, adulthood adiposity increased risk of adult-onset asthma Health sciences; Respiratory medicine; Pediatrics
登录
查看更多内容
影响因子：
16.6
作者：
Richardson, Tom G.;Crouch, Daniel J. M.;Power, Grace M.;Morales-Berstein, Fernanda;Hazelwood, Emma;Fang, Si;Cho, Yoonsu;Inshaw, Jamie R. J.;Robertson, Catherine C.;Sidore, Carlo;Cucca, Francesco;Rich, Steven S.;Todd, John A.;Smith, George Davey
通讯作者：
Smith, George Davey
影响因子：
3.5
作者：
Brandkvist M;Bjørngaard JH;Ødegård RA;Åsvold BO;Smith GD;Brumpton B;Hveem K;Richardson TG;Vie GÅ
通讯作者：
Vie GÅ
影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
影响因子：
9.8
作者：
Ferreira, Manuel A. R.;Mathur, Riddhima;Almqvist, Catarina
通讯作者：
Almqvist, Catarina
影响因子：
7.7
作者：
通讯作者：
--