Life course effects of genetic susceptibility to higher body size on body fat and lean mass: prospective cohort study.
Life course effects of genetic susceptibility to higher body size on body fat and lean mass: prospective cohort study.
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DOI：
10.1093/ije/dyad029
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发表时间：
2023-10-05
影响因子：
7.7
通讯作者：
中科院分区：
文献类型：
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作者：
不同的遗传变异与儿童期与成年期的体型较大有关。这些变异是否以及何时主要影响肥胖尚不清楚。我们研究了遗传变异如何影响全身脂肪和总瘦体重轨迹。数据来自雅芳父母和儿童出生队列纵向研究（N = 6926）。生成儿童和成年体型的性别特异性遗传风险评分（GRS），并在9至25岁之间进行6次双能X射线吸收扫描测量体脂和瘦体重。多水平线性样条模型研究了GRS与脂肪和瘦体重轨迹的相关性。在男性中，性别特异性儿童期和成年期GRS与9至18岁的脂肪量差异相似;每标准差（SD）较高的儿童期和成年期GRS，18岁时的脂肪量分别高出8.3% [95%置信区间（CI）5.1，11.6]和7.5%（95% CI 4.3，10.8）。在男性中，性别结合的儿童GRS在9至15岁时的影响比性别结合的成年GRS更强。在女性中，从9岁到18岁，性别特异性儿童期GRS的相关性几乎是成年期GRS的2倍：每SD 9岁时脂肪量增加10.5%（95% CI 8.5，12.4），儿童期GRS增加，而每SD成年期GRS增加5.1%（95% CI 3.2，6.9）。在雌性动物中，性别合并GRS具有相似的效应，效应估计值略大。瘦体重效应量要小得多。体型的遗传变异与肥胖的相关性比与瘦体重的相关性更强。性别结合的儿童期变异与肥胖增加的关系更密切，直到成年早期。这可能会为未来的研究提供信息，这些研究使用遗传学来调查肥胖在不同生命阶段的原因和影响。
Different genetic variants are associated with larger body size in childhood vs adulthood. Whether and when these variants predominantly influence adiposity are unknown. We examined how genetic variants influence total body fat and total lean mass trajectories. Data were from the Avon Longitudinal Study of Parents and Children birth cohort (N = 6926). Sex-specific genetic risk scores (GRS) for childhood and adulthood body size were generated, and dual-energy X-ray absorptiometry scans measured body fat and lean mass six times between the ages of 9 and 25 years. Multilevel linear spline models examined associations of GRS with fat and lean mass trajectories. In males, the sex-specific childhood and adulthood GRS were associated with similar differences in fat mass from 9 to 18 years; 8.3% [95% confidence interval (CI) 5.1, 11.6] and 7.5% (95% CI 4.3, 10.8) higher fat mass at 18 years per standard deviation (SD) higher childhood and adulthood GRS, respectively. In males, the sex-combined childhood GRS had stronger effects at ages 9 to 15 than the sex-combined adulthood GRS. In females, associations for the sex-specific childhood GRS were almost 2-fold stronger than the adulthood GRS from 9 to 18 years: 10.5% (95% CI 8.5, 12.4) higher fat mass at 9 years per SD higher childhood GRS compared with 5.1% (95% CI 3.2, 6.9) per-SD higher adulthood GRS. In females, the sex-combined GRS had similar effects, with slightly larger effect estimates. Lean mass effect sizes were much smaller. Genetic variants for body size are more strongly associated with adiposity than with lean mass. Sex-combined childhood variants are more strongly associated with increased adiposity until early adulthood. This may inform future studies that use genetics to investigate the causes and impact of adiposity at different life stages.
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影响因子：
3.5
作者：
Pulit SL;Stoneman C;Morris AP;Wood AR;Glastonbury CA;Tyrrell J;Yengo L;Ferreira T;Marouli E;Ji Y;Yang J;Jones S;Beaumont R;Croteau-Chonka DC;Winkler TW;GIANT Consortium;Hattersley AT;Loos RJF;Hirschhorn JN;Visscher PM;Frayling TM;Yaghootkar H;Lindgren CM
通讯作者：
Lindgren CM
影响因子：
3.5
作者：
Brandkvist M;Bjørngaard JH;Ødegård RA;Åsvold BO;Smith GD;Brumpton B;Hveem K;Richardson TG;Vie GÅ
通讯作者：
Vie GÅ
影响因子：
39.3
作者：
Lassale C;Tzoulaki I;Moons KGM;Sweeting M;Boer J;Johnson L;Huerta JM;Agnoli C;Freisling H;Weiderpass E;Wennberg P;van der A DL;Arriola L;Benetou V;Boeing H;Bonnet F;Colorado-Yohar SM;Engström G;Eriksen AK;Ferrari P;Grioni S;Johansson M;Kaaks R;Katsoulis M;Katzke V;Key TJ;Matullo G;Melander O;Molina-Portillo E;Moreno-Iribas C;Norberg M;Overvad K;Panico S;Quirós JR;Saieva C;Skeie G;Steffen A;Stepien M;Tjønneland A;Trichopoulou A;Tumino R;van der Schouw YT;Verschuren WMM;Langenberg C;Di Angelantonio E;Riboli E;Wareham NJ;Danesh J;Butterworth AS
通讯作者：
Butterworth AS
影响因子：
20.8
作者：
Helgeland, Oyvind;Vaudel, Marc;Johansson, Stefan
通讯作者：
Johansson, Stefan
影响因子：
--
作者：
Northstone, Kate;Lewcock, Melanie;Wells, Nicholas
通讯作者：
Wells, Nicholas