Traumatic brain injury and the development of parkinsonism: Understanding pathophysiology, animal models, and therapeutic targets.
Traumatic brain injury and the development of parkinsonism: Understanding pathophysiology, animal models, and therapeutic targets.
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DOI：
10.1016/j.biopha.2022.112812
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发表时间：
2022-05
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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治疗方法的临床转化，以对抗衰弱性神经退行性疾病，如帕金森病（PD），仍然是一个紧迫的未满足的挑战。创伤性脑损伤（TBI）的发病机制与人类帕金森病的发展之间的强烈的分子关联已经得到了很好的证实。因此，许多正在进行的研究旨在深入研究这种病理重叠，以开发TBI和PD的共同靶点，以制定更有效和长期的治疗策略。这篇综述文章旨在提供关于创伤性脑损伤病理生理的详细背景及其与PD的重叠，并特别强调它们对血管周围清除的影响的最新发现。尽管传统的创伤性脑损伤和帕金森病的动物模型仍在考虑之中，但人们非常关注将脑震荡与预先建立的帕金森病模型结合起来的组合杂交动物模型的发展，以便更好地概括帕金森病的人类发病背景。最后，讨论了TBI和PD的治疗靶点，以及涉及外泌体、DNA疫苗、miRNA、基因治疗和基因编辑开发潜在候选药物的当代研究，以及最近开发的微创和有前途的中枢神经系统（CNS）药物递送策略。
The clinical translation of therapeutic approaches to combat debilitating neurodegenerative conditions, such as Parkinson’s disease (PD), remains as an urgent unmet challenge. The strong molecular association between the pathogenesis of traumatic brain injury (TBI) and the development of parkinsonism in humans has been well established. Therefore, a lot of ongoing research aims to investigate this pathology overlap in-depth, to exploit the common targets of TBI and PD for development of more effective and long-term treatment strategies. This review article intends to provide a detailed background on TBI pathophysiology and its established overlap with PD with an additional emphasis on the recent findings about their effect on perivascular clearance. Although, the traditional animal models of TBI and PD are still being considered, there is a huge focus on the development of combinatory hybrid animal models coupling concussion with the pre-established PD models for a better recapitulation of the human context of PD pathogenesis. Lastly, the therapeutic targets for TBI and PD, and the contemporary research involving exosomes, DNA vaccines, miRNA, gene therapy and gene editing for the development of potential candidates are discussed, along with the recent development of lesser invasive and promising central nervous system (CNS) drug delivery strategies.
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影响因子：
64.8
作者：
Ahn, Ji Hoon;Cho, Hyunsoo;Koh, Gou Young
通讯作者：
Koh, Gou Young
影响因子：
6
作者：
Bedi, Supinder S.;Hetz, Robert;Cox, Charles S., Jr.
通讯作者：
Cox, Charles S., Jr.
影响因子：
9.3
作者：
Bedi SS;Aertker BM;Liao GP;Caplan HW;Bhattarai D;Mandy F;Mandy F;Fernandez LG;Zelnick P;Mitchell MB;Schiffer W;Johnson M;Denson E;Prabhakara K;Xue H;Smith P;Uray K;Olson SD;Mays RW;Cox CS Jr
通讯作者：
Cox CS Jr
影响因子：
6.1
作者：
Anbari F;Khalili MA;Bahrami AR;Khoradmehr A;Sadeghian F;Fesahat F;Nabi A
通讯作者：
Nabi A
影响因子：
9.9
作者：
Ayalon, L.;Borodkin, K.;Dagan, Y.
通讯作者：
Dagan, Y.