Hemoglobin Dynamics in the Skeletal Muscle of Patients with Malignant Hematopoietic Disease.
Hemoglobin Dynamics in the Skeletal Muscle of Patients with Malignant Hematopoietic Disease.
复制标题
恶性造血系统疾病患者骨骼肌中的血红蛋白动态。
DOI：
10.1007/978-3-319-91287-5_46
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Domen K.
中科院分区：
文献类型：
--
作者：
Wakasugi T;Morishita S;Kaida K;Itani Y;Kodama N;Ikegame K;Ogawa H;Domen K.
骨骼肌氧利用受损可能导致恶性造血系统疾病患者的肌无力，并可能解释这些患者对运动的血流动力学反应改变。我们研究了恶性造血系统疾病患者胫骨前肌血红蛋白参数的变化是否与年龄匹配的健康对照组不同，以及这些结果是否与肌肉力量下降有关。在16名患者和21名年龄和性别匹配的健康对照者中，在50%的最大自主收缩下重复等长收缩任务期间和之后使用近红外光谱。在健康对照组中，肌力与血红蛋白动力学之间存在相关性（分别为ΔtHbmean：r = 0.42，p < 0.05; ΔtHbmax：r = 0.575，p < 0.01），但在恶性造血系统疾病患者中不存在相关性。这项研究的结果可能表明，血红蛋白动力学期间和之后的运动是不同的恶性造血系统疾病患者和健康对照组之间。
Impaired oxygen utilization in skeletal muscle potentially contributes to muscle weakness in patients with malignant hematopoietic disease and may explain altered hemodynamic responses to exercise in these patients. We investigated whether changes in hemoglobin parameters in the tibialis anterior muscle in patients with malignant hematopoietic diseases were different from those in age-matched healthy controls and whether these results were associated with a decline in muscle strength. Near-infrared spectroscopy was used during and after a repeated isometric contraction task at 50% of maximal voluntary contraction in 16 patients and 21 age- and sex-matched healthy controls. In the healthy control group, there was a correlation between muscle strength and hemoglobin dynamics, (ΔtHbmean: r = 0.42, p < 0.05; ΔtHbmax: r = 0.575, p < 0.01, respectively) but not in patients with malignant hematopoietic disease. The results of this study may suggest that haemoglobin dynamics during and following exercise were different between patients with malignant hematopoietic disease and healthy controls.
影响因子：
20.3
作者：
Wiskemann, Joachim;Dreger, Peter;Bohus, Martin
通讯作者：
Bohus, Martin
影响因子：
4.8
作者：
Jarden, M.;Baadsgaard, M. T.;Adamsen, L.
通讯作者：
Adamsen, L.
影响因子：
3
作者：
Tachi, M;Kouzaki, M;Fukunaga, T
通讯作者：
Fukunaga, T