The role of microRNAs in ovarian cancer.
The role of microRNAs in ovarian cancer.
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DOI：
10.1155/2014/249393
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发表时间：
2014
影响因子：
--
通讯作者：
Kimura T
中科院分区：
文献类型：
--
作者：
Kinose Y;Sawada K;Nakamura K;Kimura T
卵巢癌是妇科恶性肿瘤中致死率最高的一种。其致命性可能是由于难以在早期发现，以及对晚期或复发患者缺乏有效治疗。因此，迫切需要预后和预测标记物来早期诊断并帮助优化和个性化治疗。MicroRNA是一类非编码RNA，在转录后调节靶基因的表达。它们参与癌发生、细胞周期、凋亡、增殖、侵袭、转移和化学抗性。microRNA的失调参与了包括卵巢癌在内的人类癌症的发生和发展，并且已经出现了microRNA可以作为癌基因或肿瘤抑制基因的强有力证据。已经提出了几种卵巢癌特有的microRNA特征，血清循环microRNA有可能成为有用的诊断和预后生物标志物。各种microRNA，如miR-200家族、miR-199/214簇或let-7旁系同源物中的microRNA，具有作为播散性或化疗耐药卵巢肿瘤的治疗靶点的潜力。尽管仍有许多障碍需要克服，但microRNA疗法可能成为卵巢癌预防和治疗的有力工具。在这篇综述中，我们讨论了microRNA在卵巢癌各个方面的新作用。
Ovarian cancer is the most lethal of malignant gynecological tumors. Its lethality may be due to difficulties in detecting it at an early stage and lack of effective treatments for patients with an advanced or recurrent status. Therefore, there is a strong need for prognostic and predictive markers to diagnose it early and to help optimize and personalize treatment. MicroRNAs are noncoding RNAs that regulate target genes posttranscriptionally. They are involved in carcinogenesis, cell cycle, apoptosis, proliferation, invasion, metastasis, and chemoresistance. The dysregulation of microRNAs is involved in the initiation and progression of human cancers including ovarian cancer, and strong evidence that microRNAs can act as oncogenes or tumor suppressor genes has emerged. Several microRNA signatures that are unique to ovarian cancer have been proposed, and serum-circulating microRNAs have the potential to be useful diagnostic and prognostic biomarkers. Various microRNAs such as those in the miR-200 family, the miR-199/214 cluster, or the let-7 paralogs have potential as therapeutic targets for disseminated or chemoresistant ovarian tumors. Although many obstacles need to be overcome, microRNA therapy could be a powerful tool for ovarian cancer prevention and treatment. In this review, we discuss the emerging roles of microRNAs in various aspects of ovarian cancer.
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影响因子：
4
作者：
Chen D;Zhang Y;Wang J;Chen J;Yang C;Cai K;Wang X;Shi F;Dou J
通讯作者：
Dou J
使用miRNA Mimetics在体内重新编程与肿瘤相关的树突状细胞触发了针对卵巢癌的保护性免疫。
影响因子：
11.2
作者：
Cubillos-Ruiz JR;Baird JR;Tesone AJ;Rutkowski MR;Scarlett UK;Camposeco-Jacobs AL;Anadon-Arnillas J;Harwood NM;Korc M;Fiering SN;Sempere LF;Conejo-Garcia JR
通讯作者：
Conejo-Garcia JR
影响因子：
8
作者：
Chao, A.;Lin, C-Y;Lai, C-H
通讯作者：
Lai, C-H
DOI：
10.1111/igc.0b013e3181a48cf9
发表时间：
2009-05-01
影响因子：
4.8
作者：
Flavin, Richard;Smyth, Paul;O'Leary, John J.
通讯作者：
O'Leary, John J.
影响因子：
11.2
作者：
Creighton CJ;Fountain MD;Yu Z;Nagaraja AK;Zhu H;Khan M;Olokpa E;Zariff A;Gunaratne PH;Matzuk MM;Anderson ML
通讯作者：
Anderson ML