Event-Related Potentials During Decision-Making in a Mixed-Strategy Game.
Event-Related Potentials During Decision-Making in a Mixed-Strategy Game.
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DOI：
10.3389/fnins.2021.552750
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发表时间：
2021
影响因子：
4.3
通讯作者：
Kobayashi S
中科院分区：
文献类型：
--
作者：
Chang FY;Wiratman W;Ugawa Y;Kobayashi S
我们做出的决定有时会受到与其他代理人相互作用的影响。以前的研究表明，前额叶皮质在决策过程中起着重要作用，多巴胺系统是动机、运动准备和强化学习过程的基础。然而，前额叶皮质和多巴胺能系统参与决策的生理机制仍然很不清楚。本研究旨在确定决策策略如何影响事件相关电位(ERPs)。我们还在一项随机、双盲、安慰剂对照研究中测试了多巴胺前体左旋多巴对决策和事件相关电位的影响。受试者在记录事件相关电位的同时，通过在左右两个目标之间进行选择，与对方的虚拟计算机玩家进行了一次硬币匹配任务。根据匹配硬币任务的规则，当受试者选择与对手相同的一方时，受试者赢得比赛，否则输掉比赛。我们设置了三种不同的任务规则：(1)在交替(ALT)规则下，计算机对手在顺序试验中交替做出右和左的选择；(2)在随机(RAND)规则下，对手在右和左之间随机选择；(3)在游戏规则下，对手分析受试者过去的选择来预测受试者的下一次选择，然后选择相反的一方。持续的中间事件相关电位在受试者选择目标时变得更加消极。当受试者做出反应后，对手的选择被揭示时，就会出现双相电位。RAND和GAME组受试者选择周围的ERPs均大于ALT组，左旋多巴可增强负峰电位。除了这些内侧的事件相关电位，我们还观察到额叶外侧事件相关电位被调谐到选择的方向。在RAND和GAME中，当使用左旋多巴时，信号选择性地出现在选择期附近。这些结果表明，当需要进行复杂的战略性决策时，决策过程受多巴胺系统的调节，这可能反映了多巴胺能预测误差信号对决策的更新。
The decisions we make are sometimes influenced by interactions with other agents. Previous studies have suggested that the prefrontal cortex plays an important role in decision-making and that the dopamine system underlies processes of motivation, motor preparation, and reinforcement learning. However, the physiological mechanisms underlying how the prefrontal cortex and the dopaminergic system are involved in decision-making remain largely unclear. The present study aimed to determine how decision strategies influence event-related potentials (ERPs). We also tested the effect of levodopa, a dopamine precursor, on decision-making and ERPs in a randomized double-blind placebo-controlled investigation. The subjects performed a matching-pennies task against an opposing virtual computer player by choosing between right and left targets while their ERPs were recorded. According to the rules of the matching-pennies task, the subject won the trial when they chose the same side as the opponent, and lost otherwise. We set three different task rules: (1) with the alternation (ALT) rule, the computer opponent made alternating choices of right and left in sequential trials; (2) with the random (RAND) rule, the opponent randomly chose between right and left; and (3) with the GAME rule, the opponent analyzed the subject’s past choices to predict the subject’s next choice, and then chose the opposite side. A sustained medial ERP became more negative toward the time of the subject’s target choice. A biphasic potential appeared when the opponent’s choice was revealed after the subject’s response. The ERPs around the subject’s choice were greater in RAND and GAME than in ALT, and the negative peak was enhanced by levodopa. In addition to these medial ERPs, we observed lateral frontal ERPs tuned to the choice direction. The signals emerged around the choice period selectively in RAND and GAME when levodopa was administered. These results suggest that decision processes are modulated by the dopamine system when a complex and strategic decision is required, which may reflect decision updating with dopaminergic prediction error signals.
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影响因子：
15.9
作者：
Lee D;Seo H
通讯作者：
Seo H
DOI：
10.1016/0013-4694(87)90075-7
发表时间：
1987-03-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
DICK, JPR;CANTELLO, R;MARSDEN, CD
通讯作者：
MARSDEN, CD
影响因子：
16.2
作者：
Donahue, Christopher H.;Seo, Hyojung;Lee, Daeyeol
通讯作者：
Lee, Daeyeol
影响因子：
16.2
作者：
Dorris, MC;Glimcher, PW
通讯作者：
Glimcher, PW
影响因子：
2.5
作者：
Lauwereyns, J;Sakagami, M;Hikosaka, O
通讯作者：
Hikosaka, O