C/D-box snoRNAs form methylating and non-methylating ribonucleoprotein complexes: Old dogs show new tricks.
C/D-box snoRNAs form methylating and non-methylating ribonucleoprotein complexes: Old dogs show new tricks.
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DOI：
10.1002/bies.201600264
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Stamm S
中科院分区：
文献类型：
--
作者：
Falaleeva M;Welden JR;Duncan MJ;Stamm S
C/D box snoRNA（SNORDs）是一类高度表达的短的非编码RNA，长期以来一直被认为是rRNA的2′-O-甲基化位点。然而，大约一半的人类SNORD没有可预测的rRNA靶点，并且许多SNORD与未显示rRNA缺陷的疾病相关，其中包括Prader-Willi综合征，Duplication 15 q综合征和癌症。最近的研究已经解决了这种明显的差异，表明SNORD可以调节前mRNA选择性剪接，mRNA丰度，激活酶，并被加工成类似于miRNA和piRNA的较短的ncRNA。此外，最近的生物化学研究表明，一个给定的SNORD可以形成甲基化和非甲基化的核糖核蛋白复合物，提供了一个可能的物理基础，这种多样的新功能的指示。因此，SNORD在结构和功能上比以前认为的更加多样化，并且它们在基因表达中的作用被低估。非甲基化复合物中SNORD的作用可以被寡核苷酸取代，从而可以设计出治疗Prader-Willi综合征等疾病的疗法。
C/D box snoRNAs (SNORDs) are an abundantly expressed class of short, non-coding RNAs that have been long known to perform 2′-O-methylation of rRNAs. However, approximately half of human SNORDs have no predictable rRNA targets, and numerous SNORDs have been associated with diseases that show no defects in rRNAs, among them Prader-Willi syndrome, Duplication 15q syndrome and cancer. This apparent discrepancy has been addressed by recent studies showing that SNORDs can act to regulate pre-mRNA alternative splicing, mRNA abundance, activate enzymes, and be processed into shorter ncRNAs resembling miRNAs and piRNAs. Furthermore, recent biochemical studies have shown that a given SNORD can form both methylating and non-methylating ribonucleoprotein complexes, providing an indication of the likely physical basis for such diverse new functions. Thus, SNORDs are more structurally and functionally diverse than previously thought, and their role in gene expression is under-appreciated. The action of SNORDs in non-methylating complexes can be substituted with oligonucleotides, allowing devising therapies for diseases like Prader-Willi syndrome.
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影响因子：
14.9
作者：
Deschamps-Francoeur G;Garneau D;Dupuis-Sandoval F;Roy A;Frappier M;Catala M;Couture S;Barbe-Marcoux M;Abou-Elela S;Scott MS
通讯作者：
Scott MS
影响因子：
5.9
作者：
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通讯作者：
Dong, Jin-Tang
影响因子：
4.3
作者：
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通讯作者：
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影响因子：
3.6
作者：
Garfield AS;Davies JR;Burke LK;Furby HV;Wilkinson LS;Heisler LK;Isles AR
通讯作者：
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影响因子：
5.2
作者：
Bieth, Eric;Eddiry, Sanaa;Tauber, Maithe
通讯作者：
Tauber, Maithe