Emergence of methicillin resistance predates the clinical use of antibiotics.
Emergence of methicillin resistance predates the clinical use of antibiotics.
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DOI：
10.1038/s41586-021-04265-w
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发表时间：
2022-03
期刊：
影响因子：
64.8
通讯作者：
Larsen AR
中科院分区：
文献类型：
--
作者：
Larsen J;Raisen CL;Ba X;Sadgrove NJ;Padilla-González GF;Simmonds MSJ;Loncaric I;Kerschner H;Apfalter P;Hartl R;Deplano A;Vandendriessche S;Černá Bolfíková B;Hulva P;Arendrup MC;Hare RK;Barnadas C;Stegger M;Sieber RN;Skov RL;Petersen A;Angen Ø;Rasmussen SL;Espinosa-Gongora C;Aarestrup FM;Lindholm LJ;Nykäsenoja SM;Laurent F;Becker K;Walther B;Kehrenberg C;Cuny C;Layer F;Werner G;Witte W;Stamm I;Moroni P;Jørgensen HJ;de Lencastre H;Cercenado E;García-Garrote F;Börjesson S;Hæggman S;Perreten V;Teale CJ;Waller AS;Pichon B;Curran MD;Ellington MJ;Welch JJ;Peacock SJ;Seilly DJ;Morgan FJE;Parkhill J;Hadjirin NF;Lindsay JA;Holden MTG;Edwards GF;Foster G;Paterson GK;Didelot X;Holmes MA;Harrison EM;Larsen AR
80 多年前抗生素的发现极大地改善了人类和动物的健康。尽管环境细菌的抗生素耐药性由来已久，但人类病原体的耐药性被认为是由抗生素临床使用驱动的现代现象。在这里，我们展示了耐甲氧西林金黄色葡萄球菌（一种臭名昭著的人类病原体）的特殊谱系，出现在前抗生素时代的欧洲刺猬身上。随后，这些谱系在当地刺猬种群内以及刺猬和第二宿主（包括牲畜和人类）之间传播。我们还证明刺猬皮肤癣菌刺毛癣菌产生两种β-内酰胺抗生素，这提供了一个自然选择环境，其中耐甲氧西林金黄色葡萄球菌分离株比敏感分离株具有优势。总之，这些结果表明，甲氧西林耐药性出现在前抗生素时代，是金黄色葡萄球菌对感染皮肤癣菌的刺猬定植的共同进化适应。野生动物中临床相关抗生素抗性基因的进化以及自然、农业和人类生态系统的连通性表明，使用“同一个健康”方法对于我们理解和管理抗生素抗性至关重要，抗生素抗性是全球健康、粮食安全和发展的最大威胁之一。在前抗生素时代，耐甲氧西林金黄色葡萄球菌菌株出现在欧洲刺猬身上，作为对产生抗生素的皮肤真菌的共同进化适应，并在当地刺猬种群内以及刺猬和次要宿主之间传播。
The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics. Here we show that particular lineages of methicillin-resistant Staphylococcus aureus—a notorious human pathogen—appeared in European hedgehogs in the pre-antibiotic era. Subsequently, these lineages spread within the local hedgehog populations and between hedgehogs and secondary hosts, including livestock and humans. We also demonstrate that the hedgehog dermatophyte Trichophyton erinacei produces two β-lactam antibiotics that provide a natural selective environment in which methicillin-resistant S. aureus isolates have an advantage over susceptible isolates. Together, these results suggest that methicillin resistance emerged in the pre-antibiotic era as a co-evolutionary adaptation of S. aureus to the colonization of dermatophyte-infected hedgehogs. The evolution of clinically relevant antibiotic-resistance genes in wild animals and the connectivity of natural, agricultural and human ecosystems demonstrate that the use of a One Health approach is critical for our understanding and management of antibiotic resistance, which is one of the biggest threats to global health, food security and development. Methicillin-resistant strains of Staphylococcus aureus appeared in European hedgehogs in the pre-antibiotic era as a co-evolutionary adaptation to antibiotic-producing dermatophytes and have spread within the local hedgehog populations and between hedgehogs and secondary hosts.
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影响因子：
56.3
作者：
Garcia-Alvarez, Laura;Holden, Matthew T. G.;Lindsay, Heather;Webb, Cerian R.;Brown, Derek F. J.;Curran, Martin D.;Walpole, Enid;Brooks, Karen;Pickard, Derek J.;Teale, Christopher;Parkhill, Julian;Bentley, Stephen D.;Edwards, Giles F.;Girvan, E. Kirsty;Kearns, Angela M.;Pichon, Bruno;Hill, Robert L. R.;Larsen, Anders Rhod;Skov, Robert L.;Peacock, Sharon J.;Maskell, Duncan J.;Holmes, Mark A.
通讯作者：
Holmes, Mark A.
影响因子：
5.2
作者：
Gomez, Paula;Lozano, Carmen;Torres, Carmen
通讯作者：
Torres, Carmen
使用下一代 DNA 测序数据进行变异发现和基因分型的框架。
影响因子：
30.8
作者：
通讯作者：
--
DOI：
10.1126/science.1220761
发表时间：
2012-08-31
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Forsberg KJ;Reyes A;Wang B;Selleck EM;Sommer MO;Dantas G
通讯作者：
Dantas G
DOI：
10.1093/jac/dkaa345
发表时间：
2020-12-01
期刊：
The Journal of antimicrobial chemotherapy
影响因子：
--
作者：
Bortolaia V;Kaas RS;Ruppe E;Roberts MC;Schwarz S;Cattoir V;Philippon A;Allesoe RL;Rebelo AR;Florensa AF;Fagelhauer L;Chakraborty T;Neumann B;Werner G;Bender JK;Stingl K;Nguyen M;Coppens J;Xavier BB;Malhotra-Kumar S;Westh H;Pinholt M;Anjum MF;Duggett NA;Kempf I;Nykäsenoja S;Olkkola S;Wieczorek K;Amaro A;Clemente L;Mossong J;Losch S;Ragimbeau C;Lund O;Aarestrup FM
通讯作者：
Aarestrup FM