Gene-drive into insect populations with age and spatial structure: a theoretical assessment.
Gene-drive into insect populations with age and spatial structure: a theoretical assessment.
复制标题
DOI：
10.1111/j.1752-4571.2010.00153.x
复制
发表时间：
2011-05
影响因子：
4.1
通讯作者：
Gould F
中科院分区：
文献类型：
--
作者：
Huang Y;Lloyd AL;Legros M;Gould F
在进行任何田间释放之前，必须评估转基因基因驱动系统用更良性的毒株取代野生有害生物毒株的潜在利益和风险。我们开发了一个计算机模拟模型来评估使用工程劣势构建将转基因驱动到年龄和空间结构的蚊子种群中的可行性。我们成功的实际标准是在释放后3年内实现至少0.80的转基因频率。研究了一些可能影响基因驱动成功的参数的影响，如释放面积、释放年龄、密度依赖的幼虫存活率、工程基因的适应成本和成虫的迁移概率。结果表明，与集中释放相比，局部释放通常需要释放较少的工程昆虫才能取得成功。当健身成本很低时，覆盖总面积25%的中央释放比覆盖整个面积的完全均匀释放更有效。本研究表明，在确定最佳的空间释放方法和释放工程昆虫的总数量时，应考虑释放昆虫的年龄、性别和种群的空间结构。
The potential benefits and risks of genetically engineered gene-drive systems for replacing wild pest strains with more benign strains must be assessed prior to any field releases. We develop a computer simulation model to assess the feasibility of using engineered underdominance constructs to drive transgenes into age- and spatially structured mosquito populations. Our practical criterion for success is the achievement of a transgene frequency of at least 0.80 within 3 years of release. The impacts of a number of parameters that may affect the success of gene-drive, such as the release area, release age, density-dependent larval survival, fitness cost of the engineered genes, and migration probability of adults, are examined. Results show that patchy release generally requires the release of fewer engineered insects to achieve success than central release. When the fitness cost is very low, central release covering 25% of the total area can be more effective than a completely uniform release over the whole area. This study demonstrates that to determine the best method of spatial release, and the total number of engineered insects that must be released, it is important to take into account the age and sex of the released insects and spatial structure of the population.
登录
查看更多内容
影响因子：
2
作者：
Davis, S;Bax, N;Grewe, P
通讯作者：
Grewe, P
影响因子：
1.4
作者：
LEWIS, MA;KAREIVA, P
通讯作者：
KAREIVA, P
影响因子：
2.1
作者：
Legros M;Lloyd AL;Huang Y;Gould F
通讯作者：
Gould F
DOI：
10.1111/j.1469-1809.1937.tb02153.x
发表时间：
1937-06-01
期刊：
ANNALS OF EUGENICS
影响因子：
--
作者：
Fisher, RA
通讯作者：
Fisher, RA
DOI：
10.1073/pnas.0610685104
发表时间：
2007-05-29
影响因子：
11.1
作者：
Atkinson, Michael P.;Su, Zheng;Wein, Lawrence M.
通讯作者：
Wein, Lawrence M.