Bone Morphogenetic Proteins and Diabetic Retinopathy.
Bone Morphogenetic Proteins and Diabetic Retinopathy.
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DOI：
10.3390/biom11040593
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发表时间：
2021-04-18
期刊：
影响因子：
5.5
通讯作者：
Al-Shabrawey M
中科院分区：
文献类型：
--
作者：
Elmasry K;Habib S;Moustafa M;Al-Shabrawey M
骨形态发生蛋白（BMPs）在骨形成和修复中起重要作用。最近的研究强调了它们在健康和疾病中几个器官的正常发育和血管稳态中的重要作用。骨形成蛋白水平升高与糖尿病心血管并发症的发生有关。然而，它们在糖尿病视网膜病变（DR）相关的微血管功能障碍的发病机制中的特殊作用仍有待研究。从我们和其他人的研究中积累的证据表明，BMP信号转导参与DR和年龄相关性黄斑变性（AMD）中的视网膜炎症、高通透性和病理性新生血管形成。因此，针对糖尿病中的BMP信号被提出作为一种潜在的治疗策略，以阻止视网膜疾病，特别是在DR中微血管功能障碍的发展。这篇综述文章的目标是讨论BMP的生物学功能，其潜在的机制和其在DR发病机制中的潜在作用。
Bone morphogenetic proteins (BMPs) play an important role in bone formation and repair. Recent studies underscored their essential role in the normal development of several organs and vascular homeostasis in health and diseases. Elevated levels of BMPs have been linked to the development of cardiovascular complications of diabetes mellitus. However, their particular role in the pathogenesis of microvascular dysfunction associated with diabetic retinopathy (DR) is still under-investigated. Accumulated evidence from our and others’ studies suggests the involvement of BMP signaling in retinal inflammation, hyperpermeability and pathological neovascularization in DR and age-related macular degeneration (AMD). Therefore, targeting BMP signaling in diabetes is proposed as a potential therapeutic strategy to halt the development of microvascular dysfunction in retinal diseases, particularly in DR. The goal of this review article is to discuss the biological functions of BMPs, their underlying mechanisms and their potential role in the pathogenesis of DR in particular.
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影响因子：
7.3
作者：
Al-Shabrawey M;Hussein K;Wang F;Wan M;Elmasry K;Elsherbiny N;Saleh H;Yu PB;Tawfik A;Ibrahim AS
通讯作者：
Ibrahim AS
影响因子：
5.5
作者：
Benn, Andreas;Alonso, Florian;Zwijsen, An
通讯作者：
Zwijsen, An
影响因子：
7.3
作者：
Forrester JV;Kuffova L;Delibegovic M
通讯作者：
Delibegovic M
影响因子：
--
作者：
Brooks, HL;Caballero, S;Grant, MB
通讯作者：
Grant, MB
影响因子：
4.6
作者：
Délot, EC;Bahamonde, ME;Lyons, KM
通讯作者：
Lyons, KM