Molecular and genetic substrates linking stress and addiction.
Molecular and genetic substrates linking stress and addiction.
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DOI：
10.1016/j.brainres.2009.11.002
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发表时间：
2010-02-16
期刊：
影响因子：
2.9
通讯作者：
Blendy, Julie A.
中科院分区：
文献类型：
--
作者：
Briand, Lisa A.;Blendy, Julie A.
药物成瘾是美国经济和医疗保健成本方面的三大健康问题之一。尽管如此，有效的治疗选择很少。因此，了解从偶然使用药物到强迫性药物成瘾转变的原因和分子机制有助于制定治疗方案。对人类和动物模型的研究表明，压力可能导致成瘾的脆弱性，以及增加吸毒和成瘾者的复发。暴露于压力或滥用药物导致大脑的长期适应，这可能涉及基因表达或转录因子（如cAMP反应元件结合蛋白，CREB）激活的持续改变。CREB控制的信号通路与药物成瘾和应激密切相关。基于启动子DNA序列中CRE元件的存在，已经鉴定了许多潜在的CREB靶基因。这些包括但不限于CRF、BDNF和强啡肽。这些基因与药物奖赏的启动或恢复有关，并在压力后向一个方向或另一个方向改变。虽然许多评论已经研究了压力和成瘾之间的相互作用，但本文的目的是关注在压力和成瘾中起关键作用的特定分子，因此它们可以介导两者之间的相互作用。关注这些分子可以为我们提供成瘾药物治疗的新靶点。
Drug addiction is one of the top three health concerns in the United States in terms of economic and health care costs. Despite this, there are very few effective treatment options available. Therefore, understanding the causes and molecular mechanisms underlying the transition from casual drug use to compulsive drug addiction could aid in the development of treatment options. Studies in humans and animal models indicate that stress can lead to both vulnerability to develop addiction, as well as increase drug taking and relapse in addicted individuals. Exposure to stress or drugs of abuse results in long-term adaptations in the brain that are likely to involve persistent alterations in gene expression or activation of transcription factors, such as the cAMP Response Element Binding protein, CREB. The signaling pathways controlled by CREB have been strongly implicated in drug addiction and stress. Many potential CREB target genes have been identified based on the presence of a CRE element in promoter DNA sequences. These include, but are not limited to CRF, BDNF, and dynorphin. These genes have been associated with initiation or reinstatement of drug reward and are altered in one direction or the other following stress. While many reviews have examined the interactions between stress and addiction, the goal of this review is to focus on specific molecules that play key roles in both stress and addiction and are therefore posed to mediate the interaction between the two. Focus on these molecules could provide us with new targets for pharmacological treatments for addiction.
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影响因子：
2.9
作者：
Bland, ST;Schmid, MJ;Maier, SF
通讯作者：
Maier, SF
影响因子：
6.1
作者：
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DOI：
10.1073/pnas.172091899
发表时间：
2002-08-20
影响因子：
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作者：
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DOI：
10.1016/j.pnpbp.2003.09.017
发表时间：
2003-12-01
影响因子：
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作者：
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Burton, P
影响因子：
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作者：
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