Prognostic Value of HIF-1α-Induced Genes in Sepsis/Septic Shock.
Prognostic Value of HIF-1α-Induced Genes in Sepsis/Septic Shock.
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DOI：
10.3390/medsci11020041
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发表时间：
2023-06-12
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
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作者：
缺氧是脓毒症的主要后果之一，脓毒症被认为是重症监护病房（ICU）患者死亡的主要原因。在这项研究中，我们的目的是检查是否在缺氧条件下调控基因的表达水平可以作为新的生物标志物在ICU患者脓毒症预后。在46名重症患者（最初为非脓毒症）入住ICU时，测定了低氧诱导因子-1 α（HIF 1A）、干扰素刺激基因15（ISG 15）、己糖激酶2（HK 2）、乳酸脱氢酶（LDHA）、血红素加氧酶-1（HMOX 1）、促红细胞生成素（EPO）和血管内皮生长因子A（VEGFA）的全血表达水平。随后根据脓毒症和脓毒性休克的发展（n = 25）或无脓毒症和脓毒性休克（n = 21）将患者分为两组。与非脓毒症组相比，发生脓毒症/脓毒性休克的患者中HMOX 1 mRNA表达增加（p < 0.0001）。ROC曲线、多变量logistic回归和Kaplan-Meier分析表明，HMOX 1表达可用于脓毒症和脓毒性休克发生概率。总之，我们的研究结果表明，HMOX 1 mRNA水平有可能成为ICU患者脓毒症和脓毒性休克预后的一个有价值的预测因素。
Hypoxia is characterized as one of the main consequences of sepsis, which is recognized as the leading cause of death in intensive care unit (ICU) patients. In this study, we aimed to examine whether the expression levels of genes regulated under hypoxia could be utilized as novel biomarkers for sepsis prognosis in ICU patients. Whole blood expression levels of hypoxia-inducible factor-1α (HIF1A), interferon-stimulated gene 15 (ISG15), hexokinase 2 (HK2), lactate dehydrogenase (LDHA), heme oxygenase-1 (HMOX1), erythropoietin (EPO), and the vascular endothelial growth factor A (VEGFA) were measured on ICU admission in 46 critically ill, initially non-septic patients. The patients were subsequently divided into two groups, based on the development of sepsis and septic shock (n = 25) or lack thereof (n = 21). HMOX1 mRNA expression was increased in patients who developed sepsis/septic shock compared to the non-septic group (p < 0.0001). The ROC curve, multivariate logistic regression, and Kaplan–Meier analysis demonstrated that HMOX1 expression could be utilized for sepsis and septic shock development probability. Overall, our results indicate that HMOX1 mRNA levels have the potential to be a valuable predictive factor for the prognosis of sepsis and septic shock in ICU patients.
DOI：
10.1186/cc9049
发表时间：
2010
期刊：
Critical care (London, England)
影响因子：
--
作者：
Walden AP;Young JD;Sharples E
通讯作者：
Sharples E
影响因子：
3.7
作者：
Maragno AL;Pironin M;Alcalde H;Cong X;Knobeloch KP;Tangy F;Zhang DE;Ghysdael J;Quang CT
通讯作者：
Quang CT
影响因子：
--
作者：
Xia, Shilin;Zhang, Meishuai;Liu, Han;Dong, Haibin;Wu, Nannan;Wiedermann, Christian J;Andaluz-Ojeda, David;Chen, Huiqing;Li, Nan
通讯作者：
Li, Nan