Regulation of tissue fibrosis by the biomechanical environment.
Regulation of tissue fibrosis by the biomechanical environment.
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DOI：
10.1155/2013/101979
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发表时间：
2013
影响因子：
--
通讯作者：
Goldsmith EC
中科院分区：
文献类型：
--
作者：
Carver W;Goldsmith EC
生物力学环境在胚胎发育、组织维持和发病机制中起着重要作用。机械力在结缔组织的调节中起着特别重要的作用，结缔组织不仅包括骨和软骨，而且包括大多数器官的间质组织。体内研究已经将机械负荷的变化与细胞外基质的调节相关联，并且已经表明增加的机械力有助于细胞外基质组分或纤维化的增强的表达和沉积。病理性纤维化导致许多器官系统功能障碍。各种体外模型已被用于评估机械力对细胞外基质产生细胞的影响。通常，机械拉伸、流体流动和压缩的应用导致细胞外基质组分的表达增加。最近的研究表明，组织硬度也为细胞提供促纤维化信号。细胞检测机械信号并将其转化为生化反应的机制受到了相当大的关注。细胞外基质成分的细胞表面受体和细胞内信号传导途径在机械转导过程中起作用。了解机械信号是如何从微环境中传递的，将为纤维化和其他病理状况确定新的治疗目标。
The biomechanical environment plays a fundamental role in embryonic development, tissue maintenance, and pathogenesis. Mechanical forces play particularly important roles in the regulation of connective tissues including not only bone and cartilage but also the interstitial tissues of most organs. In vivo studies have correlated changes in mechanical load to modulation of the extracellular matrix and have indicated that increased mechanical force contributes to the enhanced expression and deposition of extracellular matrix components or fibrosis. Pathological fibrosis contributes to dysfunction of many organ systems. A variety of in vitro models have been utilized to evaluate the effects of mechanical force on extracellular matrix-producing cells. In general, application of mechanical stretch, fluid flow, and compression results in increased expression of extracellular matrix components. More recent studies have indicated that tissue rigidity also provides profibrotic signals to cells. The mechanisms whereby cells detect mechanical signals and transduce them into biochemical responses have received considerable attention. Cell surface receptors for extracellular matrix components and intracellular signaling pathways are instrumental in the mechanotransduction process. Understanding how mechanical signals are transmitted from the microenvironment will identify novel therapeutic targets for fibrosis and other pathological conditions.
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DOI：
10.1038/nrm3112
发表时间：
2011-05
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.6
作者：
Atance, J;Yost, MJ;Carver, W
通讯作者：
Carver, W
影响因子：
5
作者：
Butt, RP;Bishop, JE
通讯作者：
Bishop, JE
DOI：
10.1083/jcb.200405004
发表时间：
2004-09-13
期刊：
The Journal of cell biology
影响因子：
--
作者：
Engler AJ;Griffin MA;Sen S;Bönnemann CG;Sweeney HL;Discher DE
通讯作者：
Discher DE
影响因子：
--
作者：
BORG, TK
通讯作者：
BORG, TK