The role of phenotypic plasticity in the escape of cancer cells from targeted therapy.
The role of phenotypic plasticity in the escape of cancer cells from targeted therapy.
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DOI：
10.1016/j.bcp.2016.06.014
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发表时间：
2016-12-15
影响因子：
5.8
通讯作者：
Smalley, Keiran S. M.
中科院分区：
文献类型：
--
作者：
Emmons, Michael F.;Faiao-Flores, Fernanda;Smalley, Keiran S. M.
靶向治疗已被证明对多种癌症患者产生显著的疗效。尽管最初的反应令人印象深刻，但大多数人最终都失败了，并表现出耐药性的迹象。很少有病人能被治愈。新出现的证据表明，用激酶抑制剂治疗癌细胞会导致一小部分细胞经历表型转换，进入更像胚胎的状态。这种状态类似于上皮细胞到间质细胞的转变，与耐药和肿瘤侵袭性增加有关。在这篇评论中，我们将全面分析靶向癌症治疗中胚胎逆转的机制，并回顾旨在根除逃逸细胞的潜在新治疗策略。
Targeted therapy has proven to be beneficial at producing significant responses in patients with a wide variety of cancers. Despite initially impressive responses, most individuals ultimately fail these therapies and show signs of drug resistance. Very few patients are ever cured. Emerging evidence suggests that treatment of cancer cells with kinase inhibitors leads a minor population of cells to undergo a phenotypic switch to a more embryonic-like state. The adoption of this state, which is analogous to an epithelial-to-mesenchymal transition, is associated with drug resistance and increased tumor aggressiveness. In this commentary we will provide a comprehensive analysis of the mechanisms that underlie the embryonic reversion that occurs on targeted cancer therapy and will review potential novel therapeutic strategies designed to eradicate the escaping cells.
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影响因子：
21.3
作者：
Batlle, E;Sancho, E;de Herreros, AG
通讯作者：
de Herreros, AG
DOI：
10.1073/pnas.1500722112
发表时间：
2015-07-14
影响因子：
11.1
作者：
Caino, M. Cecilia;Ghosh, Jagadish C.;Altieri, Dario C.
通讯作者：
Altieri, Dario C.
DOI：
10.1073/pnas.0905833106
发表时间：
2009-12-01
影响因子：
11.1
作者：
Emery, Caroline M.;Vijayendran, Krishna G.;Garraway, Levi A.
通讯作者：
Garraway, Levi A.
影响因子：
4.8
作者：
Dissanayake, Samudra K.;Wade, Michael;Weeraratna, Ashani T.
通讯作者：
Weeraratna, Ashani T.
影响因子：
64.8
作者：
Carreira, S;Goodall, J;Goding, CR
通讯作者：
Goding, CR