Loss of expression of the cancer stem cell marker aldehyde dehydrogenase 1 correlates with advanced-stage colorectal cancer.
Loss of expression of the cancer stem cell marker aldehyde dehydrogenase 1 correlates with advanced-stage colorectal cancer.
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DOI：
10.1016/j.amjsurg.2012.01.003
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发表时间：
2012-05
影响因子：
3
通讯作者：
Wong, Melissa H.
中科院分区：
文献类型：
--
作者：
Hessman, Crystal J.;Bubbers, Emily J.;Billingsley, Kevin G.;Herzig, Daniel O.;Wong, Melissa H.
结直肠癌的进展是由肿瘤干细胞(CSCs)介导的。我们试图确定CSC标志物乙醛脱氢酶1(ALDH1)在结直肠癌中的表达是否随AJCC分期的不同而不同，或者与临床结果相关。用ALDH1抗体对96例原发和转移性结直肠癌标本进行免疫组化染色，并进行成像以评估标志物的表达。ALDH1+细胞百分比与临床转归相关。ALDH1在结直肠癌组织中的表达高于非肿瘤组织。标记物在非转移性肿瘤中的表达最高；表达缺失与晚期和转移性疾病有关。ALDH1的表达与肿瘤的转移、复发及生存期无明显相关性。ALDH1在非转移性结直肠癌中高表达，但随着分期的进展而缺失。ALDH1可作为治疗早期结直肠癌的有效靶点，但不是晚期疾病的有效靶点。未发现ALDH1与疾病预后相关。
Colorectal cancer (CRC) progression is mediated by cancer stem cells (CSCs). We sought to determine if expression of the CSC marker aldehyde dehydrogenase 1 (ALDH1) in CRC tumors varies by AJCC stage or correlates to clinical outcomes. Primary and metastatic CRC samples from 96 patients were immunostained with antibodies to ALDH1 and imaged to evaluate marker expression. The percentage of ALDH1+ cells was correlated to clinical outcomes. ALDH1 was overexpressed in CRC tumors compared to non-neoplastic tissue. Marker expression was highest in non-metastatic tumors; loss of expression was associated with advanced stage and metastatic disease. No significant correlation was found between ALDH1 expression and metastasis, recurrence or survival. ALDH1 was highly expressed in non-metastatic CRC, but expression was lost with advancing stage. ALDH1 could be an effective therapeutic target in early CRC but not late stage disease. No correlation was found between ALDH1 and disease prognosis.
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影响因子：
8.8
作者：
通讯作者：
--
影响因子：
11.2
作者：
Huang EH;Hynes MJ;Zhang T;Ginestier C;Dontu G;Appelman H;Fields JZ;Wicha MS;Boman BM
通讯作者：
Boman BM
影响因子：
5.1
作者：
Moreb, Jan S.;Ucar, Deniz;Han, Shuhong;Amory, John K.;Goldstein, Alex S.;Ostmark, Blanca;Chang, Lung-Ji
通讯作者：
Chang, Lung-Ji
影响因子：
3.8
作者：
Kahlert C;Bergmann F;Beck J;Welsch T;Mogler C;Herpel E;Dutta S;Niemietz T;Koch M;Weitz J
通讯作者：
Weitz J
影响因子：
12.3
作者：
Carpenter AE;Jones TR;Lamprecht MR;Clarke C;Kang IH;Friman O;Guertin DA;Chang JH;Lindquist RA;Moffat J;Golland P;Sabatini DM
通讯作者：
Sabatini DM