Effects of Low-Level Blast on Neurovascular Health and Cerebral Blood Flow: Current Findings and Future Opportunities in Neuroimaging.
Effects of Low-Level Blast on Neurovascular Health and Cerebral Blood Flow: Current Findings and Future Opportunities in Neuroimaging.
复制标题
DOI：
10.3390/ijms25010642
复制
发表时间：
2024-01-04
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
低水平冲击波(LLB)暴露可导致神经健康、脑血管和脑血流量(CBF)的改变。由于缺乏急性症状，LLB或亚震荡冲击波暴露后认知问题和行为异常的发展是潜伏的。暴露于LLB的一个主要特征是引发神经血管损伤，随后发展为神经血管功能障碍。LLB暴露的临床前研究表明，在LLB后的早期和长期阶段，脑血管和血脑屏障(BBB)都会受到损害。神经成像技术，如使用磁共振成像(MRI)的动脉自旋标记(ASL)，已被用于临床研究，以了解脑血流灌注和脑血流变化对累积LLB暴露的响应。在这篇综述中，我们总结了神经影像技术，这些技术可以进一步加深我们对爆炸相关神经损伤的潜在机制的理解，特别是在LLB之后。与脑血管功能相关的神经成像有助于改进LLB的诊断和治疗策略。由于同样的成像方式可以在动物模型中捕捉到LLB暴露的影响，神经成像可以作为一种弥合缺口的诊断工具，允许更广泛地探索爆炸诱导的CBF变化与神经血管健康之间的潜在关系。提出了未来的研究方向，包括研究慢性LLB对脑血流的影响，探索LLB后自我调节障碍的机制，以及在临床前LLB模型中测量脑血管反应性(CVR)。
Low-level blast (LLB) exposure can lead to alterations in neurological health, cerebral vasculature, and cerebral blood flow (CBF). The development of cognitive issues and behavioral abnormalities after LLB, or subconcussive blast exposure, is insidious due to the lack of acute symptoms. One major hallmark of LLB exposure is the initiation of neurovascular damage followed by the development of neurovascular dysfunction. Preclinical studies of LLB exposure demonstrate impairment to cerebral vasculature and the blood–brain barrier (BBB) at both early and long-term stages following LLB. Neuroimaging techniques, such as arterial spin labeling (ASL) using magnetic resonance imaging (MRI), have been utilized in clinical investigations to understand brain perfusion and CBF changes in response to cumulative LLB exposure. In this review, we summarize neuroimaging techniques that can further our understanding of the underlying mechanisms of blast-related neurotrauma, specifically after LLB. Neuroimaging related to cerebrovascular function can contribute to improved diagnostic and therapeutic strategies for LLB. As these same imaging modalities can capture the effects of LLB exposure in animal models, neuroimaging can serve as a gap-bridging diagnostic tool that permits a more extensive exploration of potential relationships between blast-induced changes in CBF and neurovascular health. Future research directions are suggested, including investigating chronic LLB effects on cerebral perfusion, exploring mechanisms of dysautoregulation after LLB, and measuring cerebrovascular reactivity (CVR) in preclinical LLB models.
登录
查看更多内容
影响因子：
3.4
作者：
Ahlers ST;Vasserman-Stokes E;Shaughness MC;Hall AA;Shear DA;Chavko M;McCarron RM;Stone JR
通讯作者：
Stone JR
影响因子：
2.4
作者：
Bazarian, Jeffrey J.;Donnelly, Kerry;Zhong, Jianhui
通讯作者：
Zhong, Jianhui
影响因子：
2.1
作者：
Chao LL;Buckley ST;Kornak J;Schuff N;Madison C;Yaffe K;Miller BL;Kramer JH;Weiner MW
通讯作者：
Weiner MW
DOI：
10.1038/jcbfm.2009.203
发表时间：
2010-02
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.9
作者：
Benedictus MR;Leeuwis AE;Binnewijzend MA;Kuijer JP;Scheltens P;Barkhof F;van der Flier WM;Prins ND
通讯作者：
Prins ND