Traumatic brain injury: an overview of pathobiology with emphasis on military populations.
Traumatic brain injury: an overview of pathobiology with emphasis on military populations.
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DOI：
10.1038/jcbfm.2009.203
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发表时间：
2010-02
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影响因子：
--
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本文综述了非冲击性冲击波致神经损伤（BINT）的病理生物学。创伤性脑损伤（TBI）的病理生物学在历史上一直是在模拟平民人群特征的实验模型中进行研究的。这些脑损伤的特征在于对灰质和白色物质的原发性损伤以及随后在细胞、生物化学和分子水平上的继发性致病事件的演变，其共同介导广泛的神经变性。一个新兴的研究领域涉及与军事有关的脑损伤，特别是爆炸引起的脑损伤。从迄今为止的努力中可以清楚地看到，军事TBI的病理生物学，特别是BINT，具有其他类型脑损伤所没有的特征，尽管有类似的继发性损伤级联反应。原发性BINT的病理学非常复杂。它包括系统的，局部的，和大脑的反应相互作用，并经常平行发生。自主神经系统的激活、重要器官如肺和肝的突然压力增加以及神经内分泌免疫系统的激活是最重要的机制之一，这些机制显著促进了脑中的分子变化和级联损伤机制。
This review considers the pathobiology of non-impact blast-induced neurotrauma (BINT). The pathobiology of traumatic brain injury (TBI) has been historically studied in experimental models mimicking features seen in the civilian population. These brain injuries are characterized by primary damage to both gray and white matter and subsequent evolution of secondary pathogenic events at the cellular, biochemical, and molecular levels, which collectively mediate widespread neuro-degeneration. An emerging field of research addresses brain injuries related to the military, in particular blast-induced brain injuries. What is clear from the effort to date is that the pathobiology of military TBIs, particularly BINT, has characteristics not seen in other types of brain injury, despite similar secondary injury cascades. The pathobiology of primary BINT is extremely complex. It comprises systemic, local, and cerebral responses interacting and often occurring in parallel. Activation of the autonomous nervous system, sudden pressure-increase in vital organs such as lungs and liver, and activation of neuroendocrine-immune system are among the most important mechanisms significantly contributing to molecular changes and cascading injury mechanisms in the brain.
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影响因子：
4.5
作者：
Bauman, RA;Elsayed, N;Widholm, J
通讯作者：
Widholm, J
创伤性脑损伤后持续的认知功能障碍：多巴胺假说。
影响因子：
8.2
作者：
Bales, James W.;Wagner, Amy K.;Kline, Anthony E.;Dixon, C. Edward
通讯作者：
Dixon, C. Edward
DOI：
10.1097/00005373-199907000-00021
发表时间：
1999-07-01
影响因子：
--
作者：
Cernak, I;Savic, J;Jevtic, M
通讯作者：
Jevtic, M
DOI：
10.1016/j.nurt.2008.10.038
发表时间：
2009-01
期刊：
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
影响因子：
--
作者：
Byrnes KR;Loane DJ;Faden AI
通讯作者：
Faden AI
影响因子：
4.8
作者：
Armonda, Rocco A.;Bell, Randy S.;Campbell, William W.
通讯作者：
Campbell, William W.