Analysis of apoB Concentrations Across Early Adulthood and Predictors for Rates of Change Using CARDIA Study Data.
Analysis of apoB Concentrations Across Early Adulthood and Predictors for Rates of Change Using CARDIA Study Data.
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DOI：
10.1016/j.jlr.2022.100299
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发表时间：
2022-12
影响因子：
6.5
通讯作者：
Lloyd-Jones, Donald M.
中科院分区：
文献类型：
--
作者：
Wilkins, John T.;Ning, Hongyan;Sniderman, Allan;Stone, Neil;Otvos, James;Jacobs, David R.;Shah, Ravi;Murthy, Venkatesh L.;Rana, Jamal;Allen, Norrina;Lloyd-Jones, Donald M.
成年早期血液中累积暴露的载脂蛋白 B (apoB) 是动脉粥样硬化性心血管疾病风险的核心决定因素。迄今为止，apoB 在成年早期的变化模式和速率尚未被描述。在这里，我们使用 NMR 测量了参加第 2 年 (Y2)、第 7 年 (Y7)、第 15 年 (第 15 年)、第 20 年 (第 20 年) 和第 30 年 (第 30 年) 检查的多达 3055 名年轻人冠状动脉风险发展 (CARDIA) 研究参与者的 apoB 浓度。我们检查了个体水平的 apoB 变化的意大利面条图，并计算了随访期间 apoB 浓度变化的平均年化率。我们使用多变量线性回归模型来评估 CARDIA 参与者特征与 apoB 变化年化率之间的关联。在第2年和第20年apoB水平较高的个体中，男性、肥胖程度较高、HDL-C较低、健康饮食指数较低和血压较高的情况更为常见。随着时间的推移，apoB 浓度的个体间和个体内差异很大，平均 (SD) 变化率为 0.52 (1.0) mg/dl/年，年化变化率范围为 -6.26 至 +9.21 mg/dl/年。在基线时，较低的首次 apoB 测量值、女性、白人、较低的 BMI 和当前吸烟与 apoB 增加相关。我们得出的结论是，apoB 水平随时间的显着变化以及基线测量值与 apoB 变化率之间的适度关联表明，在青年期进行一次性评估后，预测个体未来 apoB 血清浓度及其累积 apoB 暴露的能力较低。
The cumulative exposure to apolipoprotein B (apoB)-containing lipoproteins in the blood during early adult life is a central determinant of atherosclerotic cardiovascular disease risk. To date, the patterns and rates of change in apoB through early adult life have not been described. Here, we used NMR to measure apoB concentrations in up to 3055 Coronary Artery Risk Development in Young Adults (CARDIA) Study participants who attended the years 2 (Y2), 7 (Y7), 15 (Y15), 20 (Y20), and 30 (Y30) exams. We examined individual-level spaghetti plots of apoB change, and we calculated average annualized rate of apoB concentration change during follow-up. We used multivariable linear regression models to assess the associations between CARDIA participant characteristics and annualized rates of apoB change. Male sex, higher measures of adiposity, lower HDL-C, lower Healthy Eating Index, and higher blood pressures were observed more commonly in individuals with higher apoB level at Y2 and Y20. Inter- and intra-individual variation in apoB concentration over time was substantial—while the mean (SD) rate of change was 0.52 (1.0) mg/dl/year, the range of annualized rates of change was −6.26 to +9.21 mg/dl/year. At baseline, lower first apoB measurement, female sex, White race, lower BMI, and current tobacco use were associated with apoB increase. We conclude that the significant variance in apoB level over time and the modest association between baseline measures and rates of apoB change suggest that the ability to predict an individual’s future apoB serum concentrations, and thus their cumulative apoB exposure, after a one-time assessment in young adulthood is low.
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影响因子：
37.8
作者：
Navar-Boggan AM;Peterson ED;D'Agostino RB Sr;Neely B;Sniderman AD;Pencina MJ
通讯作者：
Pencina MJ
影响因子：
8.9
作者：
Laddu DR;Rana JS;Murillo R;Sorel ME;Quesenberry CP Jr;Allen NB;Gabriel KP;Carnethon MR;Liu K;Reis JP;Lloyd-Jones D;Carr JJ;Sidney S
通讯作者：
Sidney S
通过降低载脂蛋白B脂蛋白早期，消除了动脉粥样硬化心血管疾病的负担。
影响因子：
5.4
作者：
Robinson JG;Williams KJ;Gidding S;Borén J;Tabas I;Fisher EA;Packard C;Pencina M;Fayad ZA;Mani V;Rye KA;Nordestgaard BG;Tybjærg-Hansen A;Douglas PS;Nicholls SJ;Pagidipati N;Sniderman A
通讯作者：
Sniderman A
影响因子：
16.2
作者：
Lewis, GF;Steiner, G
通讯作者：
Steiner, G
影响因子：
1.5
作者：
Funkhouser, Ellen;Wammack, Jennifer;Schreiner, Pamela
通讯作者：
Schreiner, Pamela