New insights into the molecular mechanisms of general anaesthetics.

New insights into the molecular mechanisms of general anaesthetics.
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DOI:
10.1111/j.1476-5381.2010.00891.x
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发表时间:
2010-09
影响因子:
7.3
通讯作者:
Chau PL
Chau PL
中科院分区:
医学2区
文献类型:
--
作者:
Chau PL

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本文通过分析我们所知道的,我们不知道的和我们想知道的,为未来如何进行全身麻醉研究提供了新的见解。我描述了以前的假设的作用机制全身麻醉剂(气体)涉及膜和蛋白受体。我提供的原因,GABA A型受体,NMDA受体和甘氨酸受体是强有力的候选人的网站的行动的GAs。接下来,我对提供作用机制的尝试进行了回顾,以及未来的研究应该如何在物理和化学方法的帮助下进行。
This paper provides new insights of how general anaesthetic research should be carried out in the future by an analysis of what we know, what we do not know and what we would like to know. I describe previous hypotheses on the mechanism of action of general anaesthetics (GAs) involving membranes and protein receptors. I provide the reasons why the GABA type A receptor, the NMDA receptor and the glycine receptor are strong candidates for the sites of action of GAs. I follow with a review on attempts to provide a mechanism of action, and how future research should be conducted with the help of physical and chemical methods.
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