The MAP1 family of microtubule-associated proteins.
The MAP1 family of microtubule-associated proteins.
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DOI：
10.1186/gb-2006-7-6-224
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发表时间：
2006
期刊：
影响因子：
12.3
通讯作者：
Dehmelt L
中科院分区：
文献类型：
--
作者：
Halpain S;Dehmelt L
MAP 1家族蛋白是经典的微管相关蛋白（MAP），其沿微管晶格结合沿着并稳定微管。MAP 1家族蛋白是经典的微管相关蛋白（MAP），其沿微管晶格结合沿着。其创始成员MAP 1A和MAP 1B主要在神经元中表达，在神经元中它们被认为在轴突和树突的形成和发育中很重要。哺乳动物基因组通常包含三个家族成员，MAP 1A，MAP 1B和一个较短的，最近发现的基因MAP 1 S。相比之下，只有一个家庭成员，Futsch，被发现在果蝇。在其初始表达后，MAP 1A和MAP 1B多肽被切割成轻链和重链，然后与单独编码的轻链3亚基（LC 3）一起组装成成熟复合物。MAP 1A和MAP 1B都以其微管稳定活性而闻名，但MAP 1蛋白也可以与其他细胞组分相互作用，包括丝状肌动蛋白和信号蛋白。此外，MAP 1A和MAP 1B的活性受上游信号传导机制控制，包括MAP激酶和糖原合成酶激酶-3 β途径。
MAP1-family proteins are classical microtubule-associated proteins (MAPs) that bind along the microtubule lattice and stabilize microtubules. MAP1-family proteins are classical microtubule-associated proteins (MAPs) that bind along the microtubule lattice. The founding members, MAP1A and MAP1B, are predominantly expressed in neurons, where they are thought to be important in the formation and development of axons and dendrites. Mammalian genomes usually contain three family members, MAP1A, MAP1B and a shorter, more recently identified gene called MAP1S. By contrast, only one family member, Futsch, is found in Drosophila. After their initial expression, the MAP1A and MAP1B polypeptides are cleaved into light and heavy chains, which are then assembled into mature complexes together with the separately encoded light chain 3 subunit (LC3). Both MAP1A and MAP1B are well known for their microtubule-stabilizing activity, but MAP1 proteins can also interact with other cellular components, including filamentous actin and signaling proteins. Furthermore, the activity of MAP1A and MAP1B is controlled by upstream signaling mechanisms, including the MAP kinase and glycogen synthase kinase-3 β pathways.
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DOI：
10.1083/jcb.138.5.1067
发表时间：
1997-09-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Felgner H;Frank R;Biernat J;Mandelkow EM;Mandelkow E;Ludin B;Matus A;Schliwa M
通讯作者：
Schliwa M
影响因子：
5.3
作者：
Bouquet, C;Soares, S;Nothias, F
通讯作者：
Nothias, F
影响因子：
3.7
作者：
Chien, CL;Lu, KS;Hirokawa, N
通讯作者：
Hirokawa, N
影响因子：
30.8
作者：
Ikeda, A;Zheng, QY;Nishina, PM
通讯作者：
Nishina, PM
MAP1B 是轴突引导所必需的，并且参与中枢和周围神经系统的发育。
影响因子：
7.8
作者：
Meixner, A;Haverkamp, S;Wässle, H;Führer, S;Thalhammer, J;Kropf, N;Bittner, RE;Lassmann, H;Wiche, G;Propst, F
通讯作者：
Propst, F