Elevated depressive affect is associated with adverse cardiovascular outcomes among African Americans with chronic kidney disease.
Elevated depressive affect is associated with adverse cardiovascular outcomes among African Americans with chronic kidney disease.
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DOI：
10.1038/ki.2011.153
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发表时间：
2011-09
影响因子：
19.6
通讯作者：
Lash, James P.
中科院分区：
文献类型：
--
作者：
Fischer, Michael J.;Kimmel, Paul L.;Greene, Tom;Gassman, Jennifer J.;Wang, Xuelei;Brooks, Deborah H.;Charleston, Jeanne;Dowie, Donna;Thornley-Brown, Denyse;Cooper, Lisa A.;Bruce, Marino A.;Kusek, John W.;Norris, Keith C.;Lash, James P.
关键词：
本研究旨在探讨非洲裔美国人肾脏疾病和高血压研究 (AASK) 队列研究中患有高血压慢性肾脏疾病的参与者抑郁情绪升高对健康结果的影响。抑郁情绪升高的定义是贝克抑郁量表 II (BDI-II) 阈值为 11 或更高、高于 14，以及分数增量为 5 个单位。 Cox回归分析用于将心血管死亡/住院、血清肌酐加倍/终末期肾病、总体住院和全因死亡与基线、最近年度就诊（随时间变化）或从基线到最近就诊的平均值（累积）评估的抑郁情绪联系起来。在 628 名基线参与者中，42% 的 BDI-II 得分为 11 或更高，26% 的得分高于 14。在 5 年随访期间，基线 BDI-II 得分为 11 或更高的参与者心血管死亡/住院的累积发生率显着高于得分 <11 的参与者。基线、时变和累积升高的抑郁情绪均与心血管死亡/住院风险显着升高相关，尤其是时变 BDI-II 评分超过 14（调整后 HR 1.63）时，但与其他结果无关。因此，抑郁情绪的升高与患有高血压性慢性肾病的非裔美国人的不良心血管结局相关。
This study was designed to examine the impact of elevated depressive affect on health outcomes among participants with hypertensive chronic kidney disease in the African-American Study of Kidney Disease and Hypertension (AASK) Cohort Study. Elevated depressive affect was defined by Beck Depression Inventory II (BDI-II) thresholds of 11 or more, above 14, and by 5-Unit increments in the score. Cox regression analyses were used to relate cardiovascular death/hospitalization, doubling of serum creatinine/end-stage renal disease, overall hospitalization, and all-cause death to depressive affect evaluated at baseline, the most recent annual visit (time-varying), or average from baseline to the most recent visit (cumulative). Among 628 participants at baseline, 42% had BDI-II scores of 11 or more and 26% had a score above 14. During a 5-year follow-up, the cumulative incidence of cardiovascular death/hospitalization was significantly greater for participants with baseline BDI-II scores of 11 or more compared with those with scores <11. The baseline, time-varying, and cumulative elevated depressive affect were each associated with a significant higher risk of cardiovascular death/hospitalization, especially with a time-varying BDI-II score over 14 (adjusted HR 1.63) but not with the other outcomes. Thus, elevated depressive affect is associated with unfavorable cardiovascular outcomes in African Americans with hypertensive chronic kidney disease.
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DOI：
10.2215/cjn.00030505
发表时间：
2006-05-01
影响因子：
9.8
作者：
Boulware, L. Ebony;Liu, Yongmei;Powe, Neil R.
通讯作者：
Powe, Neil R.
影响因子：
7
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Drayer, Rebecca A.;Piraino, Beth;Rollman, Bruce L.
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Rollman, Bruce L.
DOI：
10.1097/01.asn.0000070081.15137.c0
发表时间：
2003-07-01
影响因子：
13.6
作者：
Appel, LJ;Middleton, J;Wright, JT
通讯作者：
Wright, JT
影响因子：
13.2
作者：
Greene, Tom
通讯作者：
Greene, Tom
DOI：
10.1053/j.ajkd.2009.03.017
发表时间：
2009-09
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Hedayati SS;Minhajuddin AT;Toto RD;Morris DW;Rush AJ
通讯作者：
Rush AJ