Chronic wounds.
Chronic wounds.
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DOI：
10.1038/s41572-022-00377-3
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发表时间：
2022-07-21
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影响因子：
--
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中科院分区：
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--
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慢性创面的特点是无法在预期的时间内愈合，由于其发病率较高，以及对相关发病率和社会经济负担的认识较高，在过去几十年中已成为一个日益重要的临床问题。即使在几年前，慢性伤口的管理也依赖于过时的护理标准。然而，我们对这些慢性疾病的治疗方法最近在更好的预防、诊断和治疗方面得到了复兴。这些改进归功于基础科学的细胞和分子方面的重大进步，生物医学工程的创新和技术突破，以及我们进行良好控制和可靠临床研究的能力。这些最新进展所产生的循证方法已成为护理的新标准。与此同时，由于认识到我们对受损愈合的科学知识以及我们减少发病率、肢体丧失和死亡率的能力存在持续差距，对这些改善的满意度受到了影响。因此，评估我们所知道的和需要的，以改善我们对慢性伤口及其相关的愈合失败的了解，对于确保更好的治疗和结果至关重要。
Chronic wounds are characterized by their inability to heal within an expected timeframe and have emerged as an increasingly important clinical problem over the last several decades, due to their higher incidence and greater recognition of associated morbidity and socio-economic burden. Even up to a few years ago, the management of chronic wounds relied on standards of care that were outdated. However, our approach to these chronic conditions has recently enjoyed a renaissance in better prevention, diagnosis, and treatment. Such improvements are due to major advances in cellular and molecular aspects of basic science, in innovative and technological breakthroughs from biomedical engineering, and in our ability to conduct well controlled and reliable clinical research. The evidence-based approaches resulting from these recent advances have become the new standard of care. At the same time, satisfaction with these improvements is tempered by the recognition that persistent gaps exist in our scientific knowledge of impaired healing and our ability to lessen morbidity, loss of limb, and mortality. Therefore, taking stock of what we know and what is needed to improve our understanding of chronic wounds and their associated failure to heal is critical to ensuring better treatments and outcomes.
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影响因子：
9.6
作者：
Bosanquet, D. C.;Sanders, A. J.;Harding, K. G.
通讯作者：
Harding, K. G.
影响因子：
158.5
作者：
Boulton, AJM;Kirsner, RS;Vileikyte, L
通讯作者：
Vileikyte, L
影响因子：
13.2
作者：
Ahmed, S;O'Neill, KD;Moe, SM
通讯作者：
Moe, SM
DOI：
10.1073/pnas.1001653107
发表时间：
2010-04-13
影响因子：
11.1
作者：
Biswas, Sabyasachi;Roy, Sashwati;Sen, Chandan K.
通讯作者：
Sen, Chandan K.
影响因子：
4.3
作者：
Brockmann I;Ehrenpfordt J;Sturmheit T;Brandenburger M;Kruse C;Zille M;Rose D;Boltze J
通讯作者：
Boltze J