Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges.
Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges.
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DOI：
10.1155/2018/4623615
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发表时间：
2018
影响因子：
4.3
通讯作者：
Boltze J
中科院分区：
文献类型：
--
作者：
Brockmann I;Ehrenpfordt J;Sturmheit T;Brandenburger M;Kruse C;Zille M;Rose D;Boltze J
人体皮肤具有重要的屏障、感觉和免疫功能，所有这些都对健康和生物体完整性有重要贡献。广泛的皮肤损伤需要立即治疗和覆盖，因为大量的皮肤损失促进病原体的入侵，导致严重的体液流失，并可能最终导致死亡。由于皮肤是一个高度免疫活性的器官，自体移植是唯一可行的方法来永久关闭广泛的皮肤伤口。尽管组织保存自体移植技术的发展，如网状和Meek移植，广泛的皮肤损伤的治疗选择仍然非常有限。然而，皮肤也是干细胞和祖细胞的丰富来源。这些细胞在生理条件下促进伤口愈合，并且是旨在通过产生培养的表皮自体移植物（CEA）来增加可移植组织的组织工程方法的潜在来源。在这里，我们回顾自体组织工程的策略，以及移植产品的基础上皮肤来源的干细胞。我们还提供了该领域临床试验活动的概述，并讨论了与使用这些产品相关的翻译和临床挑战。
The human skin fulfills important barrier, sensory, and immune functions—all of which contribute significantly to health and organism integrity. Widespread skin damage requires immediate treatment and coverage because massive skin loss fosters the invasion of pathogens, causes critical fluid loss, and may ultimately lead to death. Since the skin is a highly immunocompetent organ, autologous transplants are the only viable approach to permanently close a widespread skin wound. Despite the development of tissue-saving autologous transplantation techniques such as mesh and Meek grafts, treatment options for extensive skin damage remain severely limited. Yet, the skin is also a rich source of stem and progenitor cells. These cells promote wound healing under physiological conditions and are potential sources for tissue engineering approaches aiming to augment transplantable tissue by generating cultured epidermal autografts (CEAs). Here, we review autologous tissue engineering strategies as well as transplantation products based on skin-derived stem cells. We further provide an overview of clinical trial activities in the field and discuss relevant translational and clinical challenges associated with the use of these products.
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影响因子：
9
作者：
HEIMBACH, D;LUTERMAN, A;ZAWACKI, B
通讯作者：
ZAWACKI, B
影响因子：
--
作者：
Guerra, L;Capurro, S;Pellegrini, G
通讯作者：
Pellegrini, G
影响因子：
2.7
作者：
Foubert, Philippe;Barillas, Samuel;Fraser, John K.
通讯作者：
Fraser, John K.
影响因子：
6.2
作者：
BANKSSCHLEGEL, S;GREEN, H
通讯作者：
GREEN, H
影响因子：
6.2
作者：
AUBOCK, J;IRSCHICK, E;FRITSCH, P
通讯作者：
FRITSCH, P