Dynamic changes in marital status and survival in women with breast cancer: a population-based study.
Dynamic changes in marital status and survival in women with breast cancer: a population-based study.
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DOI：
10.1038/s41598-021-84996-y
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发表时间：
2021-03-08
影响因子：
4.6
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Ding W;Ruan G;Lin Y;Zhu J;Tu C;Li Z
婚姻状况被证明是乳腺癌患者生存的独立预后因素。因此，我们努力探讨婚姻状况的动态变化对乳腺癌患者预后的影响。我们从监测、流行病学和最终结果癌症数据库中选择了符合资格标准的患者。然后，我们使用多变量Cox比例风险回归模型来分析婚姻状况的动态变化对总生存期（OS）和乳腺癌特异性特殊生存期（BCSS）预后的影响。与单身-单身组和离婚/分居/丧偶-离婚/分居/丧偶（DSW-DSW）组患者相比，已婚-已婚组患者与更好的BCSS显着相关（HR 1.13，95% CI：1.03-1.19，P<0.001；HR 1.19，95% CI： 1.14–1.25，分别为P < 0.001）和OS（分别为HR 1.25，95% CI：1.20–1.30，P < 0.001；HR 1.49，95% CI：1.45–1.54，P < 0.001）。与 DSW-DSW 组相比，单身-单身组和 DSW-已婚组表现出相似的 BCSS（分别为 HR 0.98，95% CI：0.92-1.05，P = 0.660；HR 1.06，95% CI：0.97-1.15，P = 0.193），但 OS 更好（HR 0.98，95% CI：0.92-1.05，P = 0.660） 1.14，95% CI：1.09–1.19，P < 0.001；HR 1.32，95% CI：1.25–1.40，P < 0.001）。与单身组相比，单身已婚组的 BCSS 明显更好（HR 1.21，95% CI：1.07–1.36，P = 0.003），但 OS 没有差异（HR 1.08，95% CI：0.98–1.18，P = 0.102）；与已婚-DSW组相比，已婚-已婚组表现出更好的BCSS（HR 1.11，95％CI：1.05–1.18，P< 0.001）和OS（HR 1.27，95％CI：1.22–1.32，P< 0.001）。我们的研究表明，无论以前的婚姻状况如何，已婚患者的预后都比未婚患者更好。此外，单身患者比 DSW 患者获得更好的生存结果。因此，有必要主动为单身和DSW个体提供适当的社会和心理支持，使他们受益。
Marital status proved to be an independent prognostic factor for survival in patients with breast cancer. We therefore strove to explore the impact of dynamic changes in marital status on the prognosis of breast cancer patients. We selected patients meeting the eligibility criteria from the Surveillance, Epidemiology, and End Results cancer database. We then used multivariate Cox proportional hazard regression model to analyze the effect of dynamic changes in marital status on the prognosis of overall survival (OS) and breast cancer-specific special survival (BCSS). Compared with the patients in the Single–Single group and the divorced/separated/widowed–divorced/separated/widowed (DSW–DSW) group, patients in the Married–Married group were significantly associated with better BCSS (HR 1.13, 95% CI: 1.03–1.19, P < 0.001; HR 1.19, 95% CI: 1.14–1.25, P < 0.001, respectively) and OS (HR 1.25, 95% CI: 1.20–1.30, P < 0.001; HR 1.49, 95% CI: 1.45–1.54, P < 0.001, respectively). In contrast to the DSW–DSW group, the Single–Single group and the DSW–Married group showed similar BCSS (HR 0.98, 95% CI: 0.92–1.05, P = 0.660; HR 1.06, 95% CI: 0.97–1.15, P = 0.193, respectively) but better OS (HR 1.14, 95% CI: 1.09–1.19, P < 0.001; HR 1.32, 95% CI: 1.25–1.40, P < 0.001, respectively). Compared with the Single–Single group, the Single–Married group showed significantly better BCSS (HR 1.21, 95% CI: 1.07–1.36, P = 0.003) but no difference in OS (HR 1.08, 95% CI: 0.98–1.18, P = 0.102); In contrast to the Married–DSW group, the Married–Married group exhibited better BCSS (HR 1.11, 95% CI: 1.05–1.18, P < 0.001) and OS (HR 1.27, 95% CI: 1.22–1.32, P < 0.001). Our study demonstrated that, regardless of their previous marital status, married patients had a better prognosis than unmarried patients. Moreover, single patients obtained better survival outcomes than DSW patients. Therefore, it is necessary to proactively provide single and DSW individuals with appropriate social and psychological support that would benefit them.
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影响因子：
6.2
作者：
Gomez SL;Hurley S;Canchola AJ;Keegan TH;Cheng I;Murphy JD;Clarke CA;Glaser SL;Martínez ME
通讯作者：
Martínez ME
影响因子：
10.3
作者：
Hawley, Sarah T.;Griggs, Jennifer J.;Katz, Steven J.
通讯作者：
Katz, Steven J.
DOI：
10.1093/gerona/62.8.892
发表时间：
2007-08-01
影响因子：
5.1
作者：
Ortiz, Carlos A. Reyes;Freeman, Jean L.;Goodwin, James S.
通讯作者：
Goodwin, James S.
DOI：
10.1186/bcr2647
发表时间：
2010
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Gabriel CA;Domchek SM
通讯作者：
Domchek SM
DOI：
10.1111/j.1349-7006.1989.tb02311.x
发表时间：
1989-04-01
期刊：
JAPANESE JOURNAL OF CANCER RESEARCH
影响因子：
--
作者：
KATO, I;TOMINAGA, S;TERAO, C
通讯作者：
TERAO, C