Relatively good prognosis of multiple endocrine neoplasia type 2B in Japanese: review of cases in Japan and analysis of genetic changes in tumors.
Relatively good prognosis of multiple endocrine neoplasia type 2B in Japanese: review of cases in Japan and analysis of genetic changes in tumors.
复制标题
日本2B型多发性内分泌肿瘤预后相对较好：日本病例回顾及肿瘤遗传变化分析
DOI：
10.1507/endocrj.40.649
复制
发表时间：
1993
影响因子：
2
通讯作者：
M. Itakura
中科院分区：
文献类型：
--
作者：
K. Yoshimoto;H. Iwahana;M. Itakura
Since 1968, a total of 23 patients with multiple endocrine neoplasia type 2B (MEN 2B) have been identified in Japan. The mean age at diagnosis was 20.3 years (range, 6 to 39 years). All patients had neuromas and bumpy lips. All patients underwent thyroidectomy for medullary thyroid carcinoma (MTC). Ten of 23 patients had pheochromocytomas. One patient died of cerebral bleeding at the age of 43, 2 patients died of MTC at the age of 35 and 12. Five-, 10-, and 15-year survival rates were 100%, 92%, and 88%, respectively. The clinical course of MTC in MEN 2B in Japanese is not so aggressive when compared with about a 50% 10-year survival reported for Caucasians. Genetic analysis of 4 MTC and 1 pheochromocytoma from 4 patients with MEN 2B revealed no common changes in regard to loss of heterozygosity on 21 chromosomes or point mutations of the ras, Gs alpha, or p53 genes.
遗传连锁研究将多个内分泌肿瘤 2 型基因座定位到染色体 10q11.2 上的一个小区间。
影响因子：
3.5
作者：
Gardner,E;Papi,L;Easton,DF;Cummings,T;Jackson,CE;Kaplan,M;Love,DR;Mole,SE;Moore,JK;Mulligan,LM
通讯作者：
Mulligan,LM
1p 杂合性缺失与多发性内分泌肿瘤 2 型综合征患者的嗜铬细胞瘤存在一致关联。
影响因子：
11.2
作者：
Moley,JF;Brother,MB;Fong,CT;White,PS;Baylin,SB;Nelkin,B;Wells,SA;Brodeur,GM
通讯作者：
Brodeur,GM