Somatostatin immunoreactive neurons in rat visual cortex: a light and electron microscopic study.

Somatostatin immunoreactive neurons in rat visual cortex: a light and electron microscopic study.
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大鼠视觉皮层中的生长抑素免疫反应神经元:光和电子显微镜研究。

DOI:
10.1007/bf02057910
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发表时间:
1986
期刊:
Journal of neurocytology
影响因子:
--
通讯作者:
Peters,A
Peters,A
中科院分区:
--
文献类型:
--
作者:
Meinecke,DL;Peters,A

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用生长抑素十四肽抗体在光镜和电镜下观察了大鼠视皮层生长抑素免疫反应神经元。生长抑素免疫反应阳性神经元被发现只属于非锥体类。它们主要有五种类型:树突薄或厚的多极神经元;大小不等的双极神经元;双簇神经元;水平神经元;和皮质下白色物质中的神经元。在免疫反应神经元中,多极神经元是最常见的,占总人数的30%,而双极和双簇神经元分别占免疫反应神经元总数的25%和15%;最不常见的生长抑素免疫反应神经元是水平和皮质下白色物质神经元。偶见树突粗的多极神经元有一个突出的上升树突,因此在光镜下它们类似于锥体细胞,但电子显微镜检查证实,与所有其他生长抑素阳性细胞一样,它们是非锥体神经元,因为它们的细胞体上有对称和不对称的突触。生长抑素-阳性神经元分布于皮质各层和皮质下白色物质中,但它们多见于两层,一层与II/III层重合,另一层与V和VI层重合。多极和双极神经元在这些上、下皮质层中的分布比例相似,而双簇神经元在上皮质层中更常见,水平神经元主要位于第VI层。
Somatostatin immunoreactive neurons in rat visual cortex were examined in the light and electron microscopes using an antibody to the tetradecapeptide form of somatostatin. Somatostatin immunoreactive neurons were found to belong only to non-pyramidal classes. They are of five main types: multipolar neurons with either thin or thick dendrites; small and large bipolar neurons; bitufted neurons; horizontal neurons; and neurons in the subcortical white matter. Of the immunoreactive neurons, multipolar neurons are the most common and account for 30% of the population, while bipolar and bitufted neurons make up 25% and 15% of the immunoreactive population, respectively; the least common somatostatin immunoreactive neurons are the horizontal and subcortical white matter neurons. Occasional multipolar neurons with thick dendrites have a prominent ascending dendrite so that they resemble pyramidal cells in the light microscope, but electron microscopic examination confirms that, like all other somatostatin-positive cells, they are non-pyramidal neurons, for they have both symmetric and asymmetric synapses on their cell bodies.Somatostatin-positive neurons are distributed among all the cortical layers and the subcortical white matter but they are more common in two laminae, one coinciding with layer II/III and the other with layers V and VI. The multipolar and bipolar neurons are distributed in similar proportions in these upper and lower cortical laminae, while bitufted neurons are more common in upper laminae and horizontal neurons are predominantly located in layer VI.
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