Research progress and applications of nanobody in human infectious diseases.
Research progress and applications of nanobody in human infectious diseases.
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纳米抗体在人类传染病中的研究进展及应用
DOI：
10.3389/fphar.2022.963978
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发表时间：
2022
影响因子：
5.6
通讯作者：
Luo, Wenxin
中科院分区：
文献类型：
--
作者：
Mei, Yaxian;Chen, Yuanzhi;Sivaccumar, Jwala P. P.;An, Zhiqiang;Xia, Ningshao;Luo, Wenxin
由病原微生物引起的传染病能够造成危机。除了疟疾、登革热等持续存在的传染病外，近年来新冠肺炎、埃博拉、SARS-CoV-2等传染病的恶性爆发，促使人们寻求更高效、更便捷的诊断和治疗手段。抗体因其良好的结构特点和应用前景而受到广泛关注。纳米小体是目前已知的能够稳定结合抗原的最小功能单域抗体，具有高稳定性、高亲水性、易于表达和修饰等优点。它们可以直接靶向抗原表位，也可以构建成多价纳米体或纳米体融合蛋白来发挥治疗作用。本文重点介绍了纳米体的构建方法和潜在功能，概述了纳米体的研究进展，并重点介绍了纳米体在人类传染病中的各种应用。
Infectious diseases, caused by pathogenic microorganisms, are capable of affecting crises. In addition to persistent infectious diseases such as malaria and dengue fever, the vicious outbreaks of infectious diseases such as Neocon, Ebola and SARS-CoV-2 in recent years have prompted the search for more efficient and convenient means for better diagnosis and treatment. Antibodies have attracted a lot of attention due to their good structural characteristics and applications. Nanobodies are the smallest functional single-domain antibodies known to be able to bind stably to antigens, with the advantages of high stability, high hydrophilicity, and easy expression and modification. They can directly target antigen epitopes or be constructed as multivalent nanobodies or nanobody fusion proteins to exert therapeutic effects. This paper focuses on the construction methods and potential functions of nanobodies, outlines the progress of their research, and highlights their various applications in human infectious diseases.
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