Association between cyclosporin neurotoxicity and hypomagnesaemia.
Association between cyclosporin neurotoxicity and hypomagnesaemia.
复制标题
环孢菌素神经毒性与低镁血症之间的关联。
DOI：
10.1016/s0140-6736(84)91556-3
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Thomas,ED
中科院分区：
文献类型：
--
作者：
Thompson,CB;June,CH;Sullivan,KM;Thomas,ED
所有 12 名经历环孢菌素 (CyA) 神经毒性作用的同种异体骨髓移植受者的血清镁水平均低于正常范围两个标准差以上。神经系统事件似乎分为三种不同的综合征。 7 名患者出现大发作，发生在 CyA 治疗的前几周内（中位发作时间为 12 天）。在第一次癫痫发作时，所有 7 名患者均患有低镁血症，并且在之前的 1-3 周内迅速发展。 3例患者出现4次小脑性共济失调、震颤、抑郁发作。这些亚急性发作是在长期 CyA 治疗后发生的（中位发病时间为 67 天）。每次发作都与低镁血症有关。 2 名患者在长期低镁血症后出现短暂性表达性失语。在所有情况下，通过补充足够的镁，症状都会得到缓解或不再复发。这些数据表明 CyA 神经毒性与低镁血症有关，可以通过镁替代来治疗或预防。
The serum magnesium levels of all 12 allogeneic bone-marrow transplant recipients who experienced the neurotoxic effects of cyclosporin (CyA) were more than two standard deviations below the normal range. The neurological events seemed to segregate into three separate syndromes. 7 patients had grand-mal seizures, which occurred within the first several weeks of CyA therapy (median onset 12 days). At the time of their first seizure all 7 patients had hypomagnesaemia, which had developed rapidly over the preceding 1-3 weeks. 3 patients had four episodes of cerebellar ataxia, tremor, and depression. These subacute episodes developed after prolonged CyA therapy (median onset 67 days). Each episode was associated with hypomagnesaemia. 2 patients had a transient episode of expressive aphasia following a long period of hypomagnesaemia. In all cases symptoms resolved or did not recur with adequate magnesium replacement. These data suggest that CyA neurotoxicity is associated with hypomagnesaemia and may be treated or prevented with magnesium replacement.
丹麦精神病学中央登记册。
影响因子：
--
作者：
P. Munk;P. Mortensen
通讯作者：
P. Mortensen
影响因子：
8
作者：
Ball, LK;Ball, R;Pratt, RD
通讯作者：
Pratt, RD