Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes.
Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes.
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DOI：
10.1016/j.jhin.2023.02.010
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发表时间：
2023-05
影响因子：
6.9
通讯作者：
Templeton, K.
中科院分区：
文献类型：
--
作者：
Cotton, S.;McHugh, M. P.;Dewar, R.;Haas, J. G.;Templeton, K.
苏格兰第一波严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）的流行导致了护理院的高病例数和死亡率。在洛锡安，超过三分之一的护理院报告了疫情，而对出院到护理院的医院患者的检测有限。调查在第一波流行期间从医院出院的患者作为SARS-CoV-2传入护理院的来源。于二零二零年三月一日至二零二零年五月三十一日期间，对所有出院至护理院的患者进行了临床审查。根据2019冠状病毒病（COVID-19）检测史、出院时的临床评估、全基因组测序（WGS）数据和14天的感染期，排除了流行性感冒。对临床样品进行WGS处理，并使用聚类调查和病毒流行病学工具软件将产生的共有基因组用于分析。使用电子病历获得患者时间表。总共有787名患者从医院出院到护理院。其中，776人（99%）被排除了随后将SARS-CoV-2引入护理院的可能性。然而，对于10次发作，结果是不确定的，因为在共有基因组中存在低基因组多样性或没有测序数据可用。只有一个出院事件与住院期间的阳性病例有基因组、时间和地点联系，导致他们的护理之家有10例阳性病例。大多数出院的患者被排除了将SARS-CoV-2引入护理院的可能性，这突出了在面临新出现的病毒和没有可用疫苗时筛查所有新入院患者的重要性。
The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes. To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave. A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records. In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home. The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine.
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影响因子：
6.7
作者：
Burton JK;Reid M;Gribben C;Caldwell D;Clark DN;Hanlon P;Quinn TJ;Fischbacher C;Knight P;Guthrie B;McAllister DA
通讯作者：
McAllister DA
影响因子：
6.7
作者：
van den Besselaar JH;Sikkema RS;Koene FMHPA;van Buul LW;Oude Munnink BB;Frénay I;Witt RT;Koopmans MPG;Hertogh CMPM;Buurman BM
通讯作者：
Buurman BM
DOI：
10.1016/j.lanepe.2021.100038
发表时间：
2021-04
期刊：
The Lancet regional health. Europe
影响因子：
--
作者：
Jeffery-Smith A;Dun-Campbell K;Janarthanan R;Fok J;Crawley-Boevey E;Vusirikala A;Fernandez Ruiz De Olano E;Sanchez Perez M;Tang S;Rowland TA;Wynne-Evans E;Bell A;Patel B;Amin-Chowdhury Z;Aiano F;Paranthaman K;Ma T;Saavedra-Campos M;Ellis J;Lackenby A;Whitaker H;Myers R;Höschler K;Brown K;Ramsay ME;Shetty N;Chow JY;Ladhani S;Zambon M
通讯作者：
Zambon M
DOI：
10.1093/infdis/jiac348
发表时间：
2022-11-11
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
通讯作者：
--
影响因子：
33.9
作者：
Taylor, Joanne;Carter, Rosalind J.;Lynfield, Ruth
通讯作者：
Lynfield, Ruth