The Necessity of Clinical Rh Phenotypic Serological Detection and Homotypic Infusion in Patients with Repeated Blood Transfusion
The Necessity of Clinical Rh Phenotypic Serological Detection and Homotypic Infusion in Patients with Repeated Blood Transfusion
复制标题
重复输血患者临床Rh表型血清学检测及同型输注的必要性
DOI：
10.12659/msm.921058
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发表时间：
2020-02
期刊：
影响因子：
--
通讯作者：
Jue Xie
中科院分区：
文献类型：
--
作者：
Yan Liu;Yan Lv;D;an Xu;Jianping Cao;Mengqing Wang;Jue Xie
背景 本研究分析了中国杭州地区人群Rh血型血清学表型的分布情况，并评估了其常规临床检测及同型输注的必要性。材料/方法 献血者以及可能需要（此处英文未完整表述，推测是“输血”之类的内容）的患者
Background This study analyzed the distribution of Rh serological phenotype in people living in Hangzhou, China, and assessed the necessity of its routine clinical detection and homotypic infusion. Material/Methods Blood donors and patients who might need blood transfusion were enrolled into the study, and ABO and 5 major Rh serological antigens (C, c, D, E, and e) were routinely detected. The consistent ABO and Rh serological phenotype blood was transfused between the blood donors and recipients. Irregular antibodies were screened and identified in patients before the blood transfusion. Then, the transfusion adverse effects were monitored and compared with the previous data in the hospital. Results The phenotypic frequencies of Rh blood groups were D>C>E>c>e. The CCDee was the most common phenotype and CcdEe was the least common. The detection rate of unexpected antibodies gradually increased, while the unexpected antibodies slowly decreased in the Rh system. There was a correlation between the isotypic infusion of 5 Rh antigens and the detection rate of antibodies in the Rh system (R=0.845). The adverse effects of blood transfusion declined from 19.95% in 2011 with just homotypic ABO infusion to 3.098% in 2019 with the transfusion of homotypic ABO and the 5 major Rh serological antigens. Conclusions The consistency of the transfusion with ABO and 5 significant Rh serological antigens could prevent and decrease the high frequency production of isoantibodies, which is of vital importance in reducing the incidence rate of adverse effects in patients receiving transfusions.
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影响因子：
4.4
作者：
R. Lifton;C. Sardet;J. Pouysségur;J. Lalouel
通讯作者：
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影响因子：
3.7
作者：
Makroo, Raj;Gupta, Richa;Rosamma, Nakamatathil L.
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影响因子：
3.6
作者：
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2.9
作者：
Schonewille, Henk;Honohan, Aine;Brand, Anneke
通讯作者：
Brand, Anneke
DOI：
10.1111/j.1751-553x.2007.00943.x
发表时间：
2008-06
影响因子：
3
作者：
P. Sulochana;A. Rajesh;J. Mathai;S. Sathyabhama
通讯作者：
P. Sulochana;A. Rajesh;J. Mathai;S. Sathyabhama