L-type calcium channel auto-regulation of transcription.
L-type calcium channel auto-regulation of transcription.
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DOI:
10.1016/j.ceca.2011.01.001
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发表时间:
2011-05
期刊:
影响因子:
4
通讯作者:
Crump SM
中科院分区:
文献类型:
--
作者:
Satin J;Schroder EA;Crump SM
L-type calcium channels (LTCC) impact the function of nearly all excitable cells. The classical LTCC function is to mediate trans-sarcolemmal Ca2+ flux. This review focuses on the contribution of a mobile segment of the LTCC that regulates ion channel function, and also serves as a regulator of transcription in the nucleus. Specifically we highlight recent work demonstrating an auto-feedback regulatory pathway whereby the LTCC transcription factor regulates the LTCC. Also discussed is acute and long-term regulation of function by the LTCC-transcription regulator.
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