ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.
ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.
复制标题
DOI：
10.1002/emmm.201100122
复制
发表时间：
2011-03
影响因子：
11.1
通讯作者：
Caldas, Carlos
中科院分区：
文献类型：
--
作者：
Holland, Daniel G.;Burleigh, Angela;Git, Anna;Goldgraben, Mae A.;Perez-Mancera, Pedro A.;Chin, Suet-Feung;Hurtado, Antonio;Bruna, Alejandro;Ali, H. Raza;Greenwood, Wendy;Dunning, Mark J.;Samarajiwa, Shamith;Menon, Suraj;Rueda, Oscar M.;Lynch, Andy G.;McKinney, Steven;Ellis, Ian O.;Eaves, Connie J.;Carroll, Jason S.;Curtis, Christina;Aparicio, Samuel;Caldas, Carlos
在8p12处的远程能放大在雌激素受体阳性（ER+）乳腺癌中很常见。显示出与基因和蛋白质表达增加的相关性，并与明显的表达特征和临床结果不佳有关。上皮细胞。将ZnF703指向腔内B乳腺癌中的一种新型癌基因。
The telomeric amplicon at 8p12 is common in oestrogen receptor-positive (ER+) breast cancers. Array-CGH and expression analyses of 1172 primary breast tumours revealed that ZNF703 was the single gene within the minimal amplicon and was amplified predominantly in the Luminal B subtype. Amplification was shown to correlate with increased gene and protein expression and was associated with a distinct expression signature and poor clinical outcome. ZNF703 transformed NIH 3T3 fibroblasts, behaving as a classical oncogene, and regulated proliferation in human luminal breast cancer cell lines and immortalized human mammary epithelial cells. Manipulation of ZNF703 expression in the luminal MCF7 cell line modified the effects of TGFβ on proliferation. Overexpression of ZNF703 in normal human breast epithelial cells enhanced the frequency of in vitro colony-forming cells from luminal progenitors. Taken together, these data strongly point to ZNF703 as a novel oncogene in Luminal B breast cancer.
登录
查看更多内容
影响因子：
4.5
作者：
Lin CY;Vega VB;Thomsen JS;Zhang T;Kong SL;Xie M;Chiu KP;Lipovich L;Barnett DH;Stossi F;Yeo A;George J;Kuznetsov VA;Lee YK;Charn TH;Palanisamy N;Miller LD;Cheung E;Katzenellenbogen BS;Ruan Y;Bourque G;Wei CL;Liu ET
通讯作者：
Liu ET
影响因子：
2.5
作者：
Hoyle, J;Tang, YP;Sive, H
通讯作者：
Sive, H
影响因子：
5.2
作者：
Gelsi-Boyer, W;Orsetti, B;Chaffanet, M
通讯作者：
Chaffanet, M
影响因子：
11.1
作者：
Sircoulomb, Fabrice;Nicolas, Nathalie;Ferrari, Anthony;Finetti, Pascal;Bekhouche, Ismahane;Rousselet, Estelle;Lonigro, Aurelie;Adelaide, Jose;Baudelet, Emilie;Esteyries, Severine;Wicinski, Julien;Audebert, Stephane;Charafe-Jauffret, Emmanuelle;Jacquemier, Jocelyne;Lopez, Marc;Borg, Jean-Paul;Sotirious, Christos;Popovici, Cornel;Bertucci, Francois;Birnbaum, Daniel;Chaffanet, Max;Ginestier, Christophe
通讯作者：
Ginestier, Christophe
DOI：
10.1073/pnas.0932692100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Sorlie, T;Tibshirani, R;Botstein, D
通讯作者：
Botstein, D