COVID-19 infection, admission and death and the impact of corticosteroids among people with rare autoimmune rheumatic disease during the second wave of COVID-19 in England: results from the RECORDER Project.
COVID-19 infection, admission and death and the impact of corticosteroids among people with rare autoimmune rheumatic disease during the second wave of COVID-19 in England: results from the RECORDER Project.
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DOI：
10.1093/rheumatology/kead150
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发表时间：
2023-12-01
期刊：
影响因子：
5.5
通讯作者：
Pearce, Fiona A.
中科院分区：
文献类型：
--
作者：
Rutter, Megan;Lanyon, Peter C.;Grainge, Matthew J.;Hubbard, Richard;Bythell, Mary;Stilwell, Peter;Aston, Jeanette;McPhail, Sean;Stevens, Sarah;Pearce, Fiona A.
计算在英国新冠肺炎大流行第二波期间，罕见自身免疫性风湿病患者中新冠肺炎感染率和新冠肺炎相关死亡率，并描述皮质类固醇对预后的影响。使用医院事件统计数据来识别2020年8月1日活着的人，并从整个英格兰人口中识别出RAIRD的ICD-10代码。使用链接的国家健康记录来计算截至2021年4月30日的新冠肺炎感染率和死亡率。新冠肺炎相关死亡的主要定义是死亡证明上提到新冠肺炎。NHS Digital和国家统计局的一般人口数据用于比较。30天使用皮质类固醇与新冠肺炎相关死亡、新冠肺炎相关住院和全因死亡之间的关系也被描述。168PCR330例RAIRDPCR9961例(5.92%)新冠肺炎 试验阳性。RAIRD与一般人群的年龄标化感染率比为0.99(95%CI：0.97，1.00)。1342例(0.80%)RAIRD患者在死亡证明上携带新冠肺炎，新冠肺炎相关死亡的年龄-性别标化死亡率是普通人群的2.76倍(95%CI：2.63，2.89)。使用30天皮质类固醇与新冠肺炎相关死亡之间存在剂量依赖关系。因其他原因死亡的人数没有增加。在英国第二波新冠肺炎期间，RAIRD患者感染新冠肺炎的风险与普通人群相同，但与普通人群相比，与新冠肺炎相关的死亡风险增加了2.76倍，皮质类固醇与风险增加相关。
To calculate the rates of COVID-19 infection and COVID-19-related death among people with rare autoimmune rheumatic diseases (RAIRD) during the second wave of the COVID-19 pandemic in England, and describe the impact of corticosteroids on outcomes. Hospital Episode Statistics data were used to identify people alive on 1 August 2020 with ICD-10 codes for RAIRD from the whole population of England. Linked national health records were used to calculate rates and rate ratios of COVID-19 infection and death up to 30 April 2021. Primary definition of COVID-19-related death was mention of COVID-19 on the death certificate. NHS Digital and Office for National Statistics general population data were used for comparison. The association between 30-day corticosteroid usage and COVID-19-related death, COVID-19-related hospital admissions and all-cause deaths was also described. Of 168 330 people with RAIRD, 9961 (5.92%) had a positive COVID-19 PCR test. The age-standardized infection rate ratio between RAIRD and the general population was 0.99 (95% CI: 0.97, 1.00). 1342 (0.80%) people with RAIRD died with COVID-19 on their death certificate and the age–sex-standardized mortality rate for COVID-19-related death was 2.76 (95% CI: 2.63, 2.89) times higher than in the general population. There was a dose-dependent relationship between 30-day corticosteroid usage and COVID-19-related death. There was no increase in deaths due to other causes. During the second wave of COVID-19 in England, people with RAIRD had the same risk of COVID-19 infection but a 2.76-fold increased risk of COVID-19-related death compared with the general population, with corticosteroids associated with increased risk.
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DOI：
10.1002/art.41728
发表时间：
2021-09
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Rutherford MA;Scott J;Karabayas M;Antonelou M;Gopaluni S;Gray D;Barrett J;Brix SR;Dhaun N;McAdoo SP;Smith RM;Geddes CC;Jayne D;Luqmani R;Salama AD;Little MA;Basu N;UK and Ireland Vasculitis Rare Disease Group (UKIVAS)
通讯作者：
UK and Ireland Vasculitis Rare Disease Group (UKIVAS)
影响因子：
5
作者：
de Oliveira SM;Martins LVO;Lupino-Assad AP;Medeiros-Ribeiro AC;de Moraes DA;Del-Rio APT;Oliveira MC;Sampaio-Barros PD;Kayser C
通讯作者：
Kayser C
影响因子：
2.9
作者：
Henson, Katherine E.;Brock, Rachael;Rashbass, Jem
通讯作者：
Rashbass, Jem
影响因子：
27.4
作者：
Mageau, Arthur;Papo, Thomas;Timsit, Jean-Francois
通讯作者：
Timsit, Jean-Francois
影响因子：
5.2
作者：
Balduzzi, Sara;Ruecker, Gerta;Schwarzer, Guido
通讯作者：
Schwarzer, Guido