Osteoblastogenesis and tumor growth in myeloma.
Osteoblastogenesis and tumor growth in myeloma.
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DOI：
10.3109/10428190903503438
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发表时间：
2010-02
影响因子：
2.6
通讯作者：
Yaccoby S
中科院分区：
文献类型：
--
作者：
Yaccoby S
骨髓瘤与成骨细胞生成的抑制有关，因此导致破骨细胞活性增加，并诱发典型的溶骨性骨病。骨髓瘤细胞抑制成骨细胞发生的分子机制以及成骨细胞活性增加对骨髓瘤细胞生长的影响直到最近才得到部分描述。成骨细胞生成减少是骨髓瘤患者骨祖细胞异常特性和成骨潜能受损的结果，也是骨髓瘤细胞和骨髓瘤骨内微环境细胞产生多种成骨细胞生成抑制剂的结果。然而，新的成骨细胞活化剂（如蛋白酶体抑制剂硼替佐米）能够在骨髓瘤动物模型和临床中诱导骨形成。这些药物诱导成骨细胞活性增加，通常伴随着破骨细胞生成的减少，这与减少骨髓瘤肿瘤负荷密切相关。在体外，与破骨细胞相比，成骨细胞能减弱大部分患者骨髓瘤细胞的生长；讨论了潜在的分子机制。这些研究表明，骨髓瘤细胞抑制成骨细胞形成对其有利，增加成骨细胞活性是治疗骨髓瘤骨病并同时控制骨髓瘤发展和进展的一种有希望的方法。
Myeloma is associated with suppression of osteoblastogenesis, consequentially resulting in increased osteoclast activity and induction of typical osteolytic bone disease. The molecular mechanisms by which myeloma cells suppress osteoblastogenesis and the consequences of increased osteoblast activity on myeloma cell growth have been partially delineated only recently. Reduced osteoblastogenesis is a consequence of abnormal properties and impaired osteogenic potential of osteoprogenitor cells from myeloma patients and is also the result of production of multiple osteoblastogenesis inhibitors by myeloma cells and by microenvironmental cells within the myelomatous bone. Nevertheless, novel osteoblast-activating agents (e.g. proteasome inhibitor bortezomib) are capable of inducing bone formation in myeloma animal models and clinically. These agents induce increased osteoblast activity, often coupled with a concomitant reduction in osteoclastogenesis, that is strongly associated with reduced myeloma tumor burden. In vitro, osteoblasts, in contrast to osteoclasts, attenuate the growth of myeloma cells from a large subset of patients; potential molecular mechanisms are discussed. These studies suggest that myeloma cells suppress osteoblastogenesis to their advantage and that increased osteoblast activity is a promising approach to treat myeloma bone disease and simultaneously control myeloma development and progression.
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DOI：
10.1302/0301-620x.71b2.2925748
发表时间：
1989-03-01
影响因子：
--
作者：
EVANS, CE;GALASKO, CSB;WARD, C
通讯作者：
WARD, C
影响因子：
11.4
作者：
Corre, J.;Mahtouk, K.;Bourin, P.
通讯作者：
Bourin, P.
DOI：
10.1073/pnas.0305855101
发表时间：
2004-04-20
影响因子：
11.1
作者：
Derksen, PWB;Tjin, E;Pals, ST
通讯作者：
Pals, ST
影响因子：
20.3
作者：
Ehrlich, LA;Chung, HY;Giuliani, N
通讯作者：
Giuliani, N
影响因子：
20.3
作者：
Giuliani, N;Colla, S;Rizzoli, V
通讯作者：
Rizzoli, V